Urinary 8-Iso-Prostaglandin F2[Alpha] as a Marker of Metabolic Risks in the General Japanese Population: The ROAD Study

To determine whether 8-iso-prostaglandin F2α (8-iso-PGF2α) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia]. This was a cross-sectional study of the baseline characteristics of a Japanese general popul...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2015-07, Vol.23 (7), p.1517
Main Authors: Mure, Kanae, Yoshimura, Noriko, Hashimoto, Marowa, Muraki, Shigeyuki, Oka, Hiroyuki, Tanaka, Sakae, Kawaguchi, Hiroshi, Nakamura, Kozo, Akune, Toru, Takeshita, Tatsuya
Format: Article
Language:English
Subjects:
Age
Atherosclerosis
Cardiovascular disease
Diabetes
Family medical history
Free radicals
Hypertension
Insulin resistance
Laboratories
Mens health
Metabolism
Multivariate analysis
Obesity
Oxidative stress
Public health
Studies
Urine
Womens health
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Summary:To determine whether 8-iso-prostaglandin F2α (8-iso-PGF2α) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia]. This was a cross-sectional study of the baseline characteristics of a Japanese general population cohort study: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD). Of 1,690 participants, 1,527 fulfilled all questionnaires and examinations. Free and conjugated urinary 8-iso-PGF2α levels and metabolic syndrome (MetS) components including blood pressure, HbA1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C were analyzed. The data were analyzed by ANCOVA, multiple regression analysis, and multinomial logistic analysis. 8-iso-PGF2a was significantly associated with HbA1c and significantly inversely associated with total cholesterol and non-HDL-C. Notably, IGT with an HbA1c cut-off of 5.5% was significantly associated with 8-iso-PGF2α level in participants aged ≤50 years. Multinomial logistic regression analysis revealed 8-iso-PGF2α level was significantly associated with a greater number of MetS risks present; this association was stronger in younger participants. In participants aged ≥71 years, 8-iso-PGF2α was significantly associated with a greater number of MetS risks with higher IGT cut-offs. Urinary 8-iso-PGF2α can be a reliable marker of IGT and the accumulation of MetS risks, especially in younger people.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21130