LINE-1 Retroelements Get ZAPped: e1005364

Since LINE-1 encodes only two proteins, it relies upon protein-protein and protein-RNA interactions with multiple host proteins to complete its retrotransposition cycle. SGs also frequently exchange mRNAs with cytoplasmic P-bodies (cytoplasmic granules containing RNA degradation proteins) [17]. [......

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Bibliographic Details
Published in:PLoS genetics 2015-07, Vol.11 (7)
Main Authors: Jr, Richard NMcLaughlin, Malik, Harmit S
Format: Article
Language:English
Subjects:
Genomes
Infections
Proteins
Viral infections
Viruses
Online Access:Get full text
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Summary:Since LINE-1 encodes only two proteins, it relies upon protein-protein and protein-RNA interactions with multiple host proteins to complete its retrotransposition cycle. SGs also frequently exchange mRNAs with cytoplasmic P-bodies (cytoplasmic granules containing RNA degradation proteins) [17]. [...]it is possible that LINE-1 transcript recruitment to stress granules via ZAP leads to its eventual degradation in cytoplasmic P-bodies.
ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1005364