Association analysis identifies new risk loci for congenital heart disease in Chinese populations

Our previous genome-wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) in Han Chinese. Here we identify additional loci by testing promising associations in an extended 3-stage validation consisting of 6,053 CHD cases and 7,410 controls. We find GW si...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2015-08, Vol.6 (1), p.8082, Article 8082
Main Authors: Lin, Yuan, Guo, Xuejiang, Zhao, Bijun, Liu, Juanjuan, Da, Min, Wen, Yang, Hu, Yuanli, Ni, Bixian, Zhang, Kai, Yang, Shiwei, Xu, Jing, Dai, Juncheng, Wang, Xiaowei, Xia, Yankai, Ma, Hongxia, Jin, Guangfu, Yu, Shiqiang, Liu, Jiayin, Keavney, Bernard D., Goodship, Judith A., Cordell, Heather J., Wang, Xinru, Shen, Hongbing, Sha, Jiahao, Zhou, Zuomin, Chen, Yijiang, Mo, Xuming, Luo, Lingfei, Hu, Zhibin
Format: Article
Language:English
Subjects:
631/208/205/2138
631/208/457
631/443/592/75/1539
692/420/2489/144
Asian Continental Ancestry Group - genetics
Case-Control Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Heart Defects, Congenital - ethnology
Heart Defects, Congenital - genetics
Humanities and Social Sciences
Humans
multidisciplinary
Polymorphism, Single Nucleotide
Reproducibility of Results
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our previous genome-wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) in Han Chinese. Here we identify additional loci by testing promising associations in an extended 3-stage validation consisting of 6,053 CHD cases and 7,410 controls. We find GW significant ( P
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms9082