Analysis of cardiovascular responses to the H^sub 2^S donors Na^sub 2^S and NaHS in the rat

Hydrogen sulfide (H...S) is an endogenous gaseous molecule formed from L-cysteine in vascular tissue. In the present study, cardiovascular responses to the H...S donors Na...S and NaHS were investigated in the anesthetized rat. The intravenous injections of Na...S and NaHS 0.03-0.5 mg/kg produced do...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2015-08, Vol.309 (4), p.H605
Main Authors: Yoo, Daniel, Jupiter, Ryan C, Pankey, Edward A, Reddy, Vishwaradh G, Edward, Justin A, Swan, Kevin W, Peak, Taylor C, Mostany, Ricardo, Kadowitz, Philip J
Format: Article
Language:English
Subjects:
Cardiovascular system
Heart rate
Hydrogen sulfide
Physiology
Rodents
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Summary:Hydrogen sulfide (H...S) is an endogenous gaseous molecule formed from L-cysteine in vascular tissue. In the present study, cardiovascular responses to the H...S donors Na...S and NaHS were investigated in the anesthetized rat. The intravenous injections of Na...S and NaHS 0.03-0.5 mg/kg produced dose-related decreases in systemic arterial pressure and heart rate, and at higher doses decreases in cardiac output, pulmonary arterial pressure, and systemic vascular resistance. H...S infusion studies show that decreases in systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance are well-maintained, and responses to Na...S are reversible. Decreases in heart rate were not blocked by atropine, suggesting that the bradycardia was independent of parasympathetic activation and was mediated by an effect on the sinus node. The decreases in systemic arterial pressure were not attenuated by hexamethonium, glybenclamide, N...-nitro-L-arginine methyl ester hydrochloride, sodium meclofenamate, ODQ, miconazole, 5-hydroxydecanoate, or tetraethylammonium, suggesting that ATP-sensitive potassium channels, nitric oxide, arachidonic acid metabolites, cyclic GMP, p450 epoxygenase metabolites, or large conductance calcium-activated potassium channels are not involved in mediating hypotensive responses to the H...S donors in the rat and that responses are not centrally mediated. The present data indicate that decreases in systemic arterial pressure in response to the H...S donors can be mediated by decreases in vascular resistance and cardiac output and that the donors have an effect on the sinus node independent of the parasympathetic system. The present data indicate that the mechanism of the peripherally mediated hypotensive response to the ...S donors is uncertain in the intact rat. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0363-6135
1522-1539