The possibility of using the PlasmaDeepDive™ MRM-panel in clinical diagnostics

Concentrations of 46 proteins have been determined in human blood plasma by the method of multiple reaction monitoring (MRM) using the PlasmaDeepDiveTM MRM-panel (Biognosys AG, Switzer land) for quantitative analysis of peptides. 18 of these proteins included into the group of proteins with higher c...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2015-07, Vol.9 (3), p.283-289
Main Authors: Miroshnichenko, Yu. V., Petushkova, N. A., Moskaleva, N. E., Teryaeva, N. B., Zgoda, V. G., Ilgisonis, E. V., Belyaev, A. Yu
Format: Article
Language:English
Subjects:
Biochemistry
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Medical diagnosis
Medicinal Chemistry
Plasma
Proteins
Proteomics
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Summary:Concentrations of 46 proteins have been determined in human blood plasma by the method of multiple reaction monitoring (MRM) using the PlasmaDeepDiveTM MRM-panel (Biognosys AG, Switzer land) for quantitative analysis of peptides. 18 of these proteins included into the group of proteins with higher concentrations, were also identified by method of liquid chromatography-tandem mass spectrometry (LS MS/MS) shotgun. Based on literature data it is concluded that the PlasmaDeepDiveTM MRM-panel is appli cable for studies of human plasma samples for determination of potential biomarkers of various nervous sys tem disorders.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750815030051