A new prognostic factor for the survival of patients with renal cell carcinoma developing metastatic spinal cord compression

Background and purpose This study aimed to identify a potential association of the number of involved extraspinal organs with the survival of patients with metastatic spinal cord compression (MSCC) from renal cell carcinoma. Patients and methods Data of 69 patients irradiated for MSCC from renal cel...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2014-07, Vol.190 (7), p.667-670
Main Authors: Rades, D., Weber, A., Bartscht, T., Bajrovic, A., Karstens, J.H., Schild, S.E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - radiotherapy
Carcinoma, Renal Cell - secondary
Causality
Comorbidity
Female
Germany - epidemiology
Humans
Kidney Neoplasms - mortality
Kidney Neoplasms - radiotherapy
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Prevalence
Prognosis
Radiotherapy
Retrospective Studies
Risk Factors
Spinal Cord Compression - mortality
Spinal Cord Compression - prevention & control
Spinal Neoplasms - mortality
Spinal Neoplasms - radiotherapy
Spinal Neoplasms - secondary
Survival Analysis
Treatment Outcome
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Summary:Background and purpose This study aimed to identify a potential association of the number of involved extraspinal organs with the survival of patients with metastatic spinal cord compression (MSCC) from renal cell carcinoma. Patients and methods Data of 69 patients irradiated for MSCC from renal cell carcinoma were retrospectively evaluated for survival. The prognostic value of the number of involved extraspinal organs and eight additional factors were investigated. These additional factors included age, gender, performance status, number of involved vertebrae, interval from cancer diagnosis to radiotherapy (RT) of MSCC, ambulatory status prior to RT, time developing motor deficits, and the fractionation regimen (30 Gy in 10 fractions vs. higher doses). Results The 6-month survival rates for involvement of 0, 1, and ≥ 2 extraspinal organs were 93, 57, and 21 %, respectively ( p  
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-014-0616-2