Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia

Purpose To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer. Materials and methods Data of 92 parotids (46 patients) were available. Kinetics o...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2014-10, Vol.190 (11), p.1001-1007
Main Authors: Belli, Maria Luisa, Scalco, Elisa, Sanguineti, Giuseppe, Fiorino, Claudio, Broggi, Sara, Dinapoli, Nicola, Ricchetti, Francesco, Valentini, Vincenzo, Rizzo, Giovanna, Cattaneo, Giovanni Mauro
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Acute Disease
Early Diagnosis
Female
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - radiotherapy
Humans
Italy
Male
Medicine
Medicine & Public Health
Oncology
Organ Size - radiation effects
Original Article
Parotid Gland - diagnostic imaging
Parotid Gland - radiation effects
Radiation Injuries - diagnostic imaging
Radiation Injuries - etiology
Radiotherapy
Radiotherapy, Conformal - adverse effects
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed
United States
Xerostomia - diagnostic imaging
Xerostomia - etiology
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Summary:Purpose To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer. Materials and methods Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients. Results A higher rΔρ was observed during the first compared to last week of treatment (−0,50 vs −0,05HU, p -value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82, p = 0.0001; Δvol: AUC = 0.77, p  = 0.0001). Both early rΔρ and rΔvol predict a higher “mean” acute xerostomia score (≥ median value, 1.57; p -value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / 
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-014-0669-2