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Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia
Purpose To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer. Materials and methods Data of 92 parotids (46 patients) were available. Kinetics o...
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| Published in: | Strahlentherapie und Onkologie 2014-10, Vol.190 (11), p.1001-1007 |
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| container_end_page | 1007 |
| container_issue | 11 |
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| container_title | Strahlentherapie und Onkologie |
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| creator | Belli, Maria Luisa Scalco, Elisa Sanguineti, Giuseppe Fiorino, Claudio Broggi, Sara Dinapoli, Nicola Ricchetti, Francesco Valentini, Vincenzo Rizzo, Giovanna Cattaneo, Giovanni Mauro |
| description | Purpose
To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer.
Materials and methods
Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients.
Results
A higher rΔρ was observed during the first compared to last week of treatment (−0,50 vs −0,05HU,
p
-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82,
p
= 0.0001; Δvol: AUC = 0.77,
p
= 0.0001).
Both early rΔρ and rΔvol predict a higher “mean” acute xerostomia score (≥ median value, 1.57;
p
-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / |
| doi_str_mv | 10.1007/s00066-014-0669-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1713996729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3813138121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-7f814bfbfc7462c71c1b628710894b6b0dfdc930b6cabdd9991fec85447922363</originalsourceid><addsrcrecordid>eNp1kMtKxDAUhoMoOl4ewI0EXFeTNJM0S5HxAgNuFNyFNBcnw7SpSSrO2xvpKG5cncD5_v-ED4BzjK4wQvw6IYQYqxCmVZmiIntghmktKiTE6z6YIcxFxfG8OQLHKa0RwowKegiOCOVzhmsxA9uFipst1CvVv9kEg4ODiiF7A43tk89bqHoDP8Jm7CwcojVeZ9gF453XKvvQJ6gyzCsLbeFKvDyjGqaY7_OupCyUHrOFnzaGlEPn1Sk4cGqT7NlunoCXu8Xz7UO1fLp_vL1ZVrquRa64azBtXes0p4xojjVuGWk4Ro2gLWuRcUaLGrVMq9YYIQR2VjdzSrkgpGb1CbiceocY3kebslyHMfblpMS8OBCME1EoPFG6_C9F6-QQfafiVmIkv2XLSbYssuW3bElK5mLXPLadNb-JH7sFIBOQyqr4jX9O_9v6Bca8i8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1713996729</pqid></control><display><type>article</type><title>Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia</title><source>Springer Nature</source><creator>Belli, Maria Luisa ; Scalco, Elisa ; Sanguineti, Giuseppe ; Fiorino, Claudio ; Broggi, Sara ; Dinapoli, Nicola ; Ricchetti, Francesco ; Valentini, Vincenzo ; Rizzo, Giovanna ; Cattaneo, Giovanni Mauro</creator><creatorcontrib>Belli, Maria Luisa ; Scalco, Elisa ; Sanguineti, Giuseppe ; Fiorino, Claudio ; Broggi, Sara ; Dinapoli, Nicola ; Ricchetti, Francesco ; Valentini, Vincenzo ; Rizzo, Giovanna ; Cattaneo, Giovanni Mauro</creatorcontrib><description>Purpose
To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer.
Materials and methods
Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients.
Results
A higher rΔρ was observed during the first compared to last week of treatment (−0,50 vs −0,05HU,
p
-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82,
p
= 0.0001; Δvol: AUC = 0.77,
p
= 0.0001).
Both early rΔρ and rΔvol predict a higher “mean” acute xerostomia score (≥ median value, 1.57;
p
-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / < 1.57 were −0.98 vs −0.22 HU/day respectively (
p
= 0.05).
Conclusions
Early density and volume variations accurately predict final changes of parotid glands. A higher longitudinally assessed score of acute xerostomia is well predicted by higher rΔρ and rΔvol in the first two weeks of treatment: best cut-off values were −0.50 HU/day and −380 mm
3
/day for rΔρ and rΔvol respectively. Further studies are necessary to definitively assess the potential of early density/volume changes in identifying more sensitive patients at higher risk of experiencing xerostomia.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-014-0669-2</identifier><identifier>PMID: 24756139</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Absorptiometry, Photon ; Acute Disease ; Early Diagnosis ; Female ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - radiotherapy ; Humans ; Italy ; Male ; Medicine ; Medicine & Public Health ; Oncology ; Organ Size - radiation effects ; Original Article ; Parotid Gland - diagnostic imaging ; Parotid Gland - radiation effects ; Radiation Injuries - diagnostic imaging ; Radiation Injuries - etiology ; Radiotherapy ; Radiotherapy, Conformal - adverse effects ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; United States ; Xerostomia - diagnostic imaging ; Xerostomia - etiology</subject><ispartof>Strahlentherapie und Onkologie, 2014-10, Vol.190 (11), p.1001-1007</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer Heidelberg Berlin 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-7f814bfbfc7462c71c1b628710894b6b0dfdc930b6cabdd9991fec85447922363</citedby><cites>FETCH-LOGICAL-c339t-7f814bfbfc7462c71c1b628710894b6b0dfdc930b6cabdd9991fec85447922363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24756139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belli, Maria Luisa</creatorcontrib><creatorcontrib>Scalco, Elisa</creatorcontrib><creatorcontrib>Sanguineti, Giuseppe</creatorcontrib><creatorcontrib>Fiorino, Claudio</creatorcontrib><creatorcontrib>Broggi, Sara</creatorcontrib><creatorcontrib>Dinapoli, Nicola</creatorcontrib><creatorcontrib>Ricchetti, Francesco</creatorcontrib><creatorcontrib>Valentini, Vincenzo</creatorcontrib><creatorcontrib>Rizzo, Giovanna</creatorcontrib><creatorcontrib>Cattaneo, Giovanni Mauro</creatorcontrib><title>Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><addtitle>Strahlenther Onkol</addtitle><description>Purpose
To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer.
Materials and methods
Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients.
Results
A higher rΔρ was observed during the first compared to last week of treatment (−0,50 vs −0,05HU,
p
-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82,
p
= 0.0001; Δvol: AUC = 0.77,
p
= 0.0001).
Both early rΔρ and rΔvol predict a higher “mean” acute xerostomia score (≥ median value, 1.57;
p
-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / < 1.57 were −0.98 vs −0.22 HU/day respectively (
p
= 0.05).
Conclusions
Early density and volume variations accurately predict final changes of parotid glands. A higher longitudinally assessed score of acute xerostomia is well predicted by higher rΔρ and rΔvol in the first two weeks of treatment: best cut-off values were −0.50 HU/day and −380 mm
3
/day for rΔρ and rΔvol respectively. Further studies are necessary to definitively assess the potential of early density/volume changes in identifying more sensitive patients at higher risk of experiencing xerostomia.</description><subject>Absorptiometry, Photon</subject><subject>Acute Disease</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Head and Neck Neoplasms - diagnostic imaging</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Italy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Organ Size - radiation effects</subject><subject>Original Article</subject><subject>Parotid Gland - diagnostic imaging</subject><subject>Parotid Gland - radiation effects</subject><subject>Radiation Injuries - diagnostic imaging</subject><subject>Radiation Injuries - etiology</subject><subject>Radiotherapy</subject><subject>Radiotherapy, Conformal - adverse effects</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed</subject><subject>United States</subject><subject>Xerostomia - diagnostic imaging</subject><subject>Xerostomia - etiology</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUhoMoOl4ewI0EXFeTNJM0S5HxAgNuFNyFNBcnw7SpSSrO2xvpKG5cncD5_v-ED4BzjK4wQvw6IYQYqxCmVZmiIntghmktKiTE6z6YIcxFxfG8OQLHKa0RwowKegiOCOVzhmsxA9uFipst1CvVv9kEg4ODiiF7A43tk89bqHoDP8Jm7CwcojVeZ9gF453XKvvQJ6gyzCsLbeFKvDyjGqaY7_OupCyUHrOFnzaGlEPn1Sk4cGqT7NlunoCXu8Xz7UO1fLp_vL1ZVrquRa64azBtXes0p4xojjVuGWk4Ro2gLWuRcUaLGrVMq9YYIQR2VjdzSrkgpGb1CbiceocY3kebslyHMfblpMS8OBCME1EoPFG6_C9F6-QQfafiVmIkv2XLSbYssuW3bElK5mLXPLadNb-JH7sFIBOQyqr4jX9O_9v6Bca8i8A</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Belli, Maria Luisa</creator><creator>Scalco, Elisa</creator><creator>Sanguineti, Giuseppe</creator><creator>Fiorino, Claudio</creator><creator>Broggi, Sara</creator><creator>Dinapoli, Nicola</creator><creator>Ricchetti, Francesco</creator><creator>Valentini, Vincenzo</creator><creator>Rizzo, Giovanna</creator><creator>Cattaneo, Giovanni Mauro</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20141001</creationdate><title>Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia</title><author>Belli, Maria Luisa ; Scalco, Elisa ; Sanguineti, Giuseppe ; Fiorino, Claudio ; Broggi, Sara ; Dinapoli, Nicola ; Ricchetti, Francesco ; Valentini, Vincenzo ; Rizzo, Giovanna ; Cattaneo, Giovanni Mauro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-7f814bfbfc7462c71c1b628710894b6b0dfdc930b6cabdd9991fec85447922363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorptiometry, Photon</topic><topic>Acute Disease</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Head and Neck Neoplasms - diagnostic imaging</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Italy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Organ Size - radiation effects</topic><topic>Original Article</topic><topic>Parotid Gland - diagnostic imaging</topic><topic>Parotid Gland - radiation effects</topic><topic>Radiation Injuries - diagnostic imaging</topic><topic>Radiation Injuries - etiology</topic><topic>Radiotherapy</topic><topic>Radiotherapy, Conformal - adverse effects</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed</topic><topic>United States</topic><topic>Xerostomia - diagnostic imaging</topic><topic>Xerostomia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belli, Maria Luisa</creatorcontrib><creatorcontrib>Scalco, Elisa</creatorcontrib><creatorcontrib>Sanguineti, Giuseppe</creatorcontrib><creatorcontrib>Fiorino, Claudio</creatorcontrib><creatorcontrib>Broggi, Sara</creatorcontrib><creatorcontrib>Dinapoli, Nicola</creatorcontrib><creatorcontrib>Ricchetti, Francesco</creatorcontrib><creatorcontrib>Valentini, Vincenzo</creatorcontrib><creatorcontrib>Rizzo, Giovanna</creatorcontrib><creatorcontrib>Cattaneo, Giovanni Mauro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belli, Maria Luisa</au><au>Scalco, Elisa</au><au>Sanguineti, Giuseppe</au><au>Fiorino, Claudio</au><au>Broggi, Sara</au><au>Dinapoli, Nicola</au><au>Ricchetti, Francesco</au><au>Valentini, Vincenzo</au><au>Rizzo, Giovanna</au><au>Cattaneo, Giovanni Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><stitle>Strahlenther Onkol</stitle><addtitle>Strahlenther Onkol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>190</volume><issue>11</issue><spage>1001</spage><epage>1007</epage><pages>1001-1007</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract>Purpose
To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer.
Materials and methods
Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients.
Results
A higher rΔρ was observed during the first compared to last week of treatment (−0,50 vs −0,05HU,
p
-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82,
p
= 0.0001; Δvol: AUC = 0.77,
p
= 0.0001).
Both early rΔρ and rΔvol predict a higher “mean” acute xerostomia score (≥ median value, 1.57;
p
-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / < 1.57 were −0.98 vs −0.22 HU/day respectively (
p
= 0.05).
Conclusions
Early density and volume variations accurately predict final changes of parotid glands. A higher longitudinally assessed score of acute xerostomia is well predicted by higher rΔρ and rΔvol in the first two weeks of treatment: best cut-off values were −0.50 HU/day and −380 mm
3
/day for rΔρ and rΔvol respectively. Further studies are necessary to definitively assess the potential of early density/volume changes in identifying more sensitive patients at higher risk of experiencing xerostomia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24756139</pmid><doi>10.1007/s00066-014-0669-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-7158 |
| ispartof | Strahlentherapie und Onkologie, 2014-10, Vol.190 (11), p.1001-1007 |
| issn | 0179-7158 1439-099X |
| language | eng |
| recordid | cdi_proquest_journals_1713996729 |
| source | Springer Nature |
| subjects | Absorptiometry, Photon Acute Disease Early Diagnosis Female Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - radiotherapy Humans Italy Male Medicine Medicine & Public Health Oncology Organ Size - radiation effects Original Article Parotid Gland - diagnostic imaging Parotid Gland - radiation effects Radiation Injuries - diagnostic imaging Radiation Injuries - etiology Radiotherapy Radiotherapy, Conformal - adverse effects Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed United States Xerostomia - diagnostic imaging Xerostomia - etiology |
| title | Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia |
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