The effect of trehalose 3% as adjuvant therapy on Lasik procedure

• Published in: Acta ophthalmologica (Oxford, England) England), 2015-10, Vol.93 (S255), p.n/a
• Main Authors: Mateo Orobia, A.J., Cristobal, J., Casas Pascual, P., Lafuente Ojeda, N., Perez Garcia, D., Peiro Embid, C., Korobko Kulikova, V., Del Buey, M., Lavilla, L.
• Format: Article
• Language: English
• Subjects: Ophthalmology
• ISSN: 1755-375X; 1755-3768
• DOI: 10.1111/j.1755-3768.2015.0490

Purpose The majority of all Lasik patients experience dry eye. Usually temporary it also could last for months or years. Patients with no or mild dry eye symptoms but high risk factors have better post‐LASIK outcomes when being preoperatively treated with lubricants. Surgical outcome of patients, with neither symptoms nor risk factors of having dry eye, could be maximized by optimizing the ocular surface before surgery. This study evaluated the effect of trehalose 3% eye drops (Thealoz), pre and post‐surgery use, on the postoperative ocular surface status of the patient. Methods Clinical study including 26 eyes from 13 patients, mean age of 35, having no dry eye signs or symptoms, who were scheduled for a LASIK procedure. Patients were randomly assigned to use trehalose 3% 48 h before surgery (G1; 1 drop tid) or no treatment (G2). After LASIK surgery, G1 used trehalose 3% 1 drop q4 h in association with artificial tears (hyaluronic acid ‐HA‐ 1 drop q4 h) and G2 used only artificial tears (1 drop q4 h) for 90 days, as corneal hydrating treatment. Results OSDI score obtained during follow‐up period showed a positive evolution in G1 compared to G2 (no statistical significance). Frequency and severity of the symptoms from first day after surgery were significantly lower in G1 (p