Pathophysiology of macular hole formation

Summary Purpose Our understanding of the pathophysiology of macular hole development has evolved in line with a novel classification system. As novel pharmacological treatments have been introduced previously unseen interactions with the pathophysiology have been observed. Methods Histopathological...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2015-10, Vol.93 (S255), p.n/a
Main Author: Stappler, T.
Format: Article
Language:English
Subjects:
Ophthalmology
Online Access:Get full text
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Summary:Summary Purpose Our understanding of the pathophysiology of macular hole development has evolved in line with a novel classification system. As novel pharmacological treatments have been introduced previously unseen interactions with the pathophysiology have been observed. Methods Histopathological correlation studies as well as the effects of novel pharmacological agents on the pathogenesis of macular holes will be presented, including rare cases of macular hole formation. Results Perifoveal PVD with vitreomacular adhesion and vitreoschisis allow cortical vitreous to remain on the retinal surface and become a scaffold for cell proliferation and form epiretinal membranes. These alter the cleavage plane for the surgeon. Pharmacological vitreolysis leads to novel and challenging clinical scenarios. The Liverpool experience will be shared. Conclusions Histopathological correlation studies demonstrate a large proportion of additional epiretinal membrane components on peeled internal limiting membranes. In pharmacological vitreolysis novel strategies in the management of macular holes will be presented.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2015.0187