Pathophysiology of macular hole formation

Summary Purpose Our understanding of the pathophysiology of macular hole development has evolved in line with a novel classification system. As novel pharmacological treatments have been introduced previously unseen interactions with the pathophysiology have been observed. Methods Histopathological...

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Published in:Acta ophthalmologica (Oxford, England) England), 2015-10, Vol.93 (S255), p.n/a
Main Author: Stappler, T.
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Language:English
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Ophthalmology
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description Summary Purpose Our understanding of the pathophysiology of macular hole development has evolved in line with a novel classification system. As novel pharmacological treatments have been introduced previously unseen interactions with the pathophysiology have been observed. Methods Histopathological correlation studies as well as the effects of novel pharmacological agents on the pathogenesis of macular holes will be presented, including rare cases of macular hole formation. Results Perifoveal PVD with vitreomacular adhesion and vitreoschisis allow cortical vitreous to remain on the retinal surface and become a scaffold for cell proliferation and form epiretinal membranes. These alter the cleavage plane for the surgeon. Pharmacological vitreolysis leads to novel and challenging clinical scenarios. The Liverpool experience will be shared. Conclusions Histopathological correlation studies demonstrate a large proportion of additional epiretinal membrane components on peeled internal limiting membranes. In pharmacological vitreolysis novel strategies in the management of macular holes will be presented.
doi_str_mv 10.1111/j.1755-3768.2015.0187
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As novel pharmacological treatments have been introduced previously unseen interactions with the pathophysiology have been observed. Methods Histopathological correlation studies as well as the effects of novel pharmacological agents on the pathogenesis of macular holes will be presented, including rare cases of macular hole formation. Results Perifoveal PVD with vitreomacular adhesion and vitreoschisis allow cortical vitreous to remain on the retinal surface and become a scaffold for cell proliferation and form epiretinal membranes. These alter the cleavage plane for the surgeon. Pharmacological vitreolysis leads to novel and challenging clinical scenarios. The Liverpool experience will be shared. Conclusions Histopathological correlation studies demonstrate a large proportion of additional epiretinal membrane components on peeled internal limiting membranes. In pharmacological vitreolysis novel strategies in the management of macular holes will be presented.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2015.0187</identifier><language>eng</language><publisher>Malden: Wiley Subscription Services, Inc</publisher><subject>Ophthalmology</subject><ispartof>Acta ophthalmologica (Oxford, England), 2015-10, Vol.93 (S255), p.n/a</ispartof><rights>2015 Acta Ophthalmologica Scandinavica Foundation. 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title Pathophysiology of macular hole formation
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