Histological, ultrastructural and immunohistochemical studies on the protective effect of ginger extract against cisplatin-induced nephrotoxicity in male rats

Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE)...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology and industrial health 2015-10, Vol.31 (10), p.869-880
Main Authors: Ali, Doaa A, Abdeen, Ahmed M, Ismail, Mohammed F, Mostafa, Mai A
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - pathology
Animals
Aquatic plants
bcl-2-Associated X Protein - analysis
bcl-2-Associated X Protein - chemistry
Body Weight
Cisplatin - toxicity
Creatinine
Immunohistochemistry
Kidney - chemistry
Kidney - drug effects
Kidney - pathology
Kidney - ultrastructure
Kidneys
Male
Microscopy, Electron, Transmission
Plant Extracts - pharmacology
Protective Agents - pharmacology
Rats
Side effects
Toxicology
Urea
Zingiber officinale - chemistry
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced nephrotoxicity. CP group displayed a marked renal failure characterized by a significant increase in serum creatinine and blood urea nitrogen (BUN) levels in addition to severe histopathological and ultrastructural renal alterations. Also, CP group showed an increase in the immunohistochemical expression of Bax proapoptotic protein. In contrast, GE+CP group showed significant decrease in the elevated serum creatinine and BUN levels and an improvement in the histopathological and ultrastructural renal injury induced by CP. The overexpression of Bax proapoptotic protein was significantly decreased in the GE+CP group. Hence, the present results indicated that GE has a protective effect against CP-induced renal damage in rats. Thereby, such findings recommended the usage of GE to prevent and/or decrease the renal damage induced by CP chemotherapeutic treatment.
ISSN:0748-2337
1477-0393
DOI:10.1177/0748233713483198