Antidiabetic effect of Pistacia atlantica and Amygdalus scoparia in streptozotocin-induced diabetic mice

Diabetes mellitus (DM) is a growing health concern worldwide. Many traditional treatments have been recommended in the alternative system of medicine for treatment of DM. Pistacia atlantica and Amygdalus scoparia have a long history as a medicinal plant since the ancient times. The present study eva...

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Bibliographic Details
Published in:Comparative clinical pathology 2015-11, Vol.24 (6), p.1301-1306
Main Authors: Hashemnia, Mohammad, Nikousefat, Zahra, Yazdani-Rostam, Masoumeh
Format: Article
Language:English
Subjects:
Hematology
Medicine
Medicine & Public Health
Oncology
Original Article
Pathology
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Summary:Diabetes mellitus (DM) is a growing health concern worldwide. Many traditional treatments have been recommended in the alternative system of medicine for treatment of DM. Pistacia atlantica and Amygdalus scoparia have a long history as a medicinal plant since the ancient times. The present study evaluated the differential effects of N-hexane extraction of these plants on the blood glucose concentration and the pathology of the pancreas in diabetic mice. DM was induced in 40 out of 50 adult female mice, using intraperitoneal injection of 60 mg/kg BW streptozotocin. The diabetic mice were assigned into four groups, three of which were treated with extract of garlic and P. atlantica , A. scoparia , and glibenclamide (200 mg/kg) for 15 days and the mice of the fourth group, as the untreated group, received ordinary diet. Ten nondiabetic mice remained as the normal control group. The results of this study indicate that these plants were able to reduce blood glucose significantly compared with the control diabetic group ( P  
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-015-2068-1