Flaxseed oil reduces oxidative stress and enhances brain monoamines release in streptozotocin-induced diabetic rats

This study was performed to investigate the biochemical effect of flaxseed oil on oxidative stress and brain monoamines release in streptozotocin-induced diabetic rats. Sixty male albino rats were divided into following four groups (15 for each group): control group, flaxseed oil group, diabetic gro...

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Bibliographic Details
Published in:Human & experimental toxicology 2015-11, Vol.34 (11), p.1133-1138
Main Authors: Badawy, EA, Rasheed, WI, Elias, TR, Hussein, J, Harvi, M, Morsy, S, Mahmoud, YA El-Latif
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - analysis
Brain
Brain - drug effects
Brain - metabolism
Diabetes
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - metabolism
Dietary Supplements
Dopamine - metabolism
Flax
Insulin - blood
Linseed Oil - pharmacology
Male
Malondialdehyde - metabolism
Nitric Oxide - metabolism
Norepinephrine - metabolism
Oils & fats
Oxidative stress
Oxidative Stress - drug effects
Rats, Sprague-Dawley
Rodents
Serotonin - metabolism
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Summary:This study was performed to investigate the biochemical effect of flaxseed oil on oxidative stress and brain monoamines release in streptozotocin-induced diabetic rats. Sixty male albino rats were divided into following four groups (15 for each group): control group, flaxseed oil group, diabetic group, and flaxseed oil-treated diabetic group. Serum glucose, insulin, pentosidine, plasma advanced oxidation protein products (AOPPs), and plasma total antioxidant capacity were estimated. Brain neurotransmitters, malondialdehyde (MDA), and nitric oxide (NO) were also determined. The mean values of serum pentosidine and plasma AOPP showed a significant decrease in treated diabetic group as compared to their values in the diabetic group. Also, brain neurotransmitters levels were improved after treatment with flaxseed. Brain MDA and NO were increased significantly in the diabetic group, while they were significantly decreased after treatment. Brain NO and brain MDA had a significant positive correlation with pentosidine, AOPP, and neurotransmitters. We concluded that flaxseed oil supplementation may be useful in the treatment of brain dysfunction in diabetes.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327115571765