GW26-e4725 MicroRNA-21 Regulates Post-Ischemic Inflammation Triggered by DAMPs in Myocardial Infarction Through Targeting STK40

Overexpression of miR-21 mimics notably increased the production of IL-1β, IL-6, IL-12 and TNF-α in mouse macrophages stimulated with rmHSP60 or rmHMGB1. [...]the phosphorylated levels of ERK, JNK, p38 and IKK-α/β were significantly increased when overexpression of miR-21 mimics in the rmHSP60 o...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C25-C25
Main Authors: Yang, Linshan, Fan, Huimin, Liu, Zhongmin, Zhan, Zhenzhen
Format: Article
Language:English
Subjects:
Adenoviruses
Cardiology
Cardiovascular
Cytokines
Heart attacks
Inflammation
Internal Medicine
MicroRNAs
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Summary:Overexpression of miR-21 mimics notably increased the production of IL-1β, IL-6, IL-12 and TNF-α in mouse macrophages stimulated with rmHSP60 or rmHMGB1. [...]the phosphorylated levels of ERK, JNK, p38 and IKK-α/β were significantly increased when overexpression of miR-21 mimics in the rmHSP60 or rmHmGB1-stimulatedmacrophages. MiR-21 inhibits the protein and mRNA expression levels of the STK40 in mouse macrophages, together with previous study that STK40 is the negative regulator of MAPK and NF-κB pathway, these data indicate that miR-21 promote MI-induced inflammatory response by regulating the target gene STK40.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.1124