GW26-e5324 Study on Cross-immunization Protection of Coxsackievirus B3 gene vaccine

Results After pcDNA3CVB3VP1 gene vaccine were identified, it was showed that aimed CVB3VP1 fragment were conjuncted with plasmid pcDNA3; results of neutralization tests indicate that pathological changes of Hela cells infected by CVB1, CVB3, CVB3m and CVB5 were attenuated due to adding serum from mi...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C68-C68
Main Authors: Xiao, Jianmin, Fan, Zhiqing
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Infections
Internal Medicine
Plasmids
Vaccines
Online Access:Get full text
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Summary:Results After pcDNA3CVB3VP1 gene vaccine were identified, it was showed that aimed CVB3VP1 fragment were conjuncted with plasmid pcDNA3; results of neutralization tests indicate that pathological changes of Hela cells infected by CVB1, CVB3, CVB3m and CVB5 were attenuated due to adding serum from mice bodies inoculated with coxsackievirus B3. [...]attenuating degree of pathological changes of Hela cells was different which were infected by different types of viruses.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.1284