GW26-e2106 The Impact of the Drug Composition Containing Medicine Serum Contains Cassia Twig Liquorice Decoction Components on ICa- L of Guinea Pig Single Ventricular Myocyte

Methods Preparing the medicated serum of rats, acute isolated guinea pigs single ventricular myocyte, will receive the ventricular muscle cells suspension after returning to the physiologic calcium concentration, respectively with blank group containing the concentration of 15% (irrigation suits sal...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C23-C23
Main Authors: Wang, Yongxia, Xing, Zuoying, Zhu, Chulin, Cao, Yingjie, Yuan, Shuangxing, Liu, Hongjun, Wang, Youping, Gao, Yuan, Li, Bin, Zhu, Mingjun
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Chinese medicine
Internal Medicine
Kinases
Rodents
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methods Preparing the medicated serum of rats, acute isolated guinea pigs single ventricular myocyte, will receive the ventricular muscle cells suspension after returning to the physiologic calcium concentration, respectively with blank group containing the concentration of 15% (irrigation suits saline), licorice group (liquorice decoction), cassia twig group (cassia twig decoction), liquorice and cassia twig group (liquorice decoction and cassia twig decoction mixed) and cassia twig liquorice decoction group (cassia twig and licorice by 2:1 ratio mixed decoction), in the medicated serum of rats in 37 °C, 5% CO2 incubation box incubating cells after 24 hours, switch to the corresponding myocardial cell inside and outside liquid, patch clamp technique was used to measure the peak current density, the activation and inactivation time constant, recovery time constant of the myocardial cells of ICa-L, change between groups were analyzed.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.06.1116