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GW26-e2106 The Impact of the Drug Composition Containing Medicine Serum Contains Cassia Twig Liquorice Decoction Components on ICa- L of Guinea Pig Single Ventricular Myocyte

Methods Preparing the medicated serum of rats, acute isolated guinea pigs single ventricular myocyte, will receive the ventricular muscle cells suspension after returning to the physiologic calcium concentration, respectively with blank group containing the concentration of 15% (irrigation suits sal...

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Published in:Journal of the American College of Cardiology 2015-10, Vol.66 (16), p.C23-C23
Main Authors: Wang, Yongxia, Xing, Zuoying, Zhu, Chulin, Cao, Yingjie, Yuan, Shuangxing, Liu, Hongjun, Wang, Youping, Gao, Yuan, Li, Bin, Zhu, Mingjun
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container_issue 16
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container_title Journal of the American College of Cardiology
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creator Wang, Yongxia
Xing, Zuoying
Zhu, Chulin
Cao, Yingjie
Yuan, Shuangxing
Liu, Hongjun
Wang, Youping
Gao, Yuan
Li, Bin
Zhu, Mingjun
description Methods Preparing the medicated serum of rats, acute isolated guinea pigs single ventricular myocyte, will receive the ventricular muscle cells suspension after returning to the physiologic calcium concentration, respectively with blank group containing the concentration of 15% (irrigation suits saline), licorice group (liquorice decoction), cassia twig group (cassia twig decoction), liquorice and cassia twig group (liquorice decoction and cassia twig decoction mixed) and cassia twig liquorice decoction group (cassia twig and licorice by 2:1 ratio mixed decoction), in the medicated serum of rats in 37 °C, 5% CO2 incubation box incubating cells after 24 hours, switch to the corresponding myocardial cell inside and outside liquid, patch clamp technique was used to measure the peak current density, the activation and inactivation time constant, recovery time constant of the myocardial cells of ICa-L, change between groups were analyzed.
doi_str_mv 10.1016/j.jacc.2015.06.1116
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subjects Cardiology
Cardiovascular
Chinese medicine
Internal Medicine
Kinases
Rodents
title GW26-e2106 The Impact of the Drug Composition Containing Medicine Serum Contains Cassia Twig Liquorice Decoction Components on ICa- L of Guinea Pig Single Ventricular Myocyte
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