Directed Amination of Non-Acidic Arene CH Bonds by a Copper-Silver Catalytic System

Amine meets arene: A method for direct amination of [beta]-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as we...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-06, Vol.52 (23), p.6043
Main Authors: Tran, Ly Dieu, Roane, James, Daugulis, Olafs
Format: Article
Language:English
Online Access:Get full text
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Summary:Amine meets arene: A method for direct amination of [beta]-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as well as providing a straightforward means for the preparation of ortho-aminobenzoic acid derivatives.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300135