A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case–control study

An aberrant up-regulation of HOX transcript antisense intergenic RNA ( HOTAIR ), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T...

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Bibliographic Details
Published in:Familial cancer 2015-12, Vol.14 (4), p.561-567
Main Authors: Bayram, Süleyman, Ülger, Yakup, Sümbül, Ahmet Taner, Kaya, Berrin Yalınbaş, Rencüzoğulları, Ahmet, Genç, Ahmet, Sevgiler, Yusuf, Bozkurt, Onur, Rencüzoğulları, Eyyüp
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Case-Control Studies
Epidemiology
Female
Follow-Up Studies
Genetic Predisposition to Disease
Human Genetics
Humans
Male
Middle Aged
Neoplasm Staging
Original Article
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide - genetics
Prognosis
Real-Time Polymerase Chain Reaction
RNA, Long Noncoding - genetics
Stomach Neoplasms - epidemiology
Stomach Neoplasms - genetics
Turkey - epidemiology
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Summary:An aberrant up-regulation of HOX transcript antisense intergenic RNA ( HOTAIR ), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. To investigate the association of the HOTAIR rs920778 polymorphism on the risk of GC susceptibility in Turkish population, a hospital-based case–control study was carried out consisting of 104 GC and 209 healthy control subjects matched on age and gender. The genotype frequency of HOTAIR rs920778 polymorphism was determined by using TaqMan Real-Time Polymerase Chain Reaction. No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs920778 polymorphism among GC and healthy control subjects ( P  > 0.05). Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins.
ISSN:1389-9600
1573-7292
DOI:10.1007/s10689-015-9813-0