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Renal Effects of Coronary Artery Bypass Graft Surgery in Diabetic and Non-Diabetic Patients: A Study with Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C
Background/Aims: Cardiac surgery and diabetes are major causes of acute kidney injury (AKI). We aimed to investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C, as early biomarkers for prediction of AKI in diabetic and non-diabetic adult patients unde...
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| Published in: | Kidney & blood pressure research 2015-01, Vol.40 (2), p.141-152 |
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| container_end_page | 152 |
| container_issue | 2 |
| container_start_page | 141 |
| container_title | Kidney & blood pressure research |
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| creator | Arun, Oguzhan Celik, Gulperi Oc, Bahar Unlu, Ali Celik, Jale Bengi Oc, Mehmet Duman, Ates |
| description | Background/Aims: Cardiac surgery and diabetes are major causes of acute kidney injury (AKI). We aimed to investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C, as early biomarkers for prediction of AKI in diabetic and non-diabetic adult patients undergoing cardiac surgery. Methods: 15 non-diabetic and 15 diabetic adult patients undergoing cardiac surgery were enrolled. Peri-operative clinical and laboratory variables were recorded. Urinary NGAL, serum cystatin C, serum creatinine (Cre) and blood urea nitrogen (BUN) were evaluated. Results: AKI was detected in 4 patients in non-diabetic group and 12 patients in diabetic group. Urinary NGAL levels of diabetic and non-diabetic patients and serum cystatin C levels of diabetic patients exceed upper normal limits or cutoff values much earlier than BUN and Cre. cystatin C levels of non-diabetic patients remain unchanged. Cystatin C and NGAL levels of patients meeting AKI criteria and NGAL levels of patients not meeting AKI criteria exceeded upper normal limits or cut off values much earlier in than BUN and Cre. Conclusions: Measurement of cystatin C level in both diabetic and non-diabetic patients may reveal AKI earlier than NGAL and BUN. In diabetic patients, measurement of urinary NGAL and serum cystatin C levels may indicate AKI signs earlier than BUN and Cre. |
| doi_str_mv | 10.1159/000368490 |
| format | article |
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We aimed to investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C, as early biomarkers for prediction of AKI in diabetic and non-diabetic adult patients undergoing cardiac surgery. Methods: 15 non-diabetic and 15 diabetic adult patients undergoing cardiac surgery were enrolled. Peri-operative clinical and laboratory variables were recorded. Urinary NGAL, serum cystatin C, serum creatinine (Cre) and blood urea nitrogen (BUN) were evaluated. Results: AKI was detected in 4 patients in non-diabetic group and 12 patients in diabetic group. Urinary NGAL levels of diabetic and non-diabetic patients and serum cystatin C levels of diabetic patients exceed upper normal limits or cutoff values much earlier than BUN and Cre. cystatin C levels of non-diabetic patients remain unchanged. Cystatin C and NGAL levels of patients meeting AKI criteria and NGAL levels of patients not meeting AKI criteria exceeded upper normal limits or cut off values much earlier in than BUN and Cre. Conclusions: Measurement of cystatin C level in both diabetic and non-diabetic patients may reveal AKI earlier than NGAL and BUN. In diabetic patients, measurement of urinary NGAL and serum cystatin C levels may indicate AKI signs earlier than BUN and Cre.</description><identifier>ISSN: 1420-4096</identifier><identifier>EISSN: 1423-0143</identifier><identifier>DOI: 10.1159/000368490</identifier><identifier>PMID: 25832128</identifier><identifier>CODEN: RPBIEL</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acute kidney injury ; Acute Kidney Injury - epidemiology ; Acute Kidney Injury - etiology ; Acute-Phase Proteins - urine ; Aged ; Aged, 80 and over ; Anesthesia ; Biomarkers ; Blood Urea Nitrogen ; Coronary Artery Bypass - adverse effects ; Coronary artery bypass graft surgery ; Creatinine - blood ; Cystatin C ; Cystatin C - urine ; Diabetes ; Diabetes Complications - metabolism ; Female ; Humans ; Kidney Function Tests ; Lipocalin-2 ; Lipocalins - urine ; Male ; Middle Aged ; Neutrophil gelatinase-associated lipocalin ; Original Paper ; Predictive Value of Tests ; Proto-Oncogene Proteins - urine ; Treatment Outcome ; Urodynamics</subject><ispartof>Kidney & blood pressure research, 2015-01, Vol.40 (2), p.141-152</ispartof><rights>2015 S. Karger AG, Basel</rights><rights>2015 S. Karger AG, Basel.</rights><rights>Copyright S. Karger AG Apr 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-4efacd13663c913ab366e7c2f122a55e44656ac3c40dcaf5d3cae28de70e23313</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27635,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25832128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arun, Oguzhan</creatorcontrib><creatorcontrib>Celik, Gulperi</creatorcontrib><creatorcontrib>Oc, Bahar</creatorcontrib><creatorcontrib>Unlu, Ali</creatorcontrib><creatorcontrib>Celik, Jale Bengi</creatorcontrib><creatorcontrib>Oc, Mehmet</creatorcontrib><creatorcontrib>Duman, Ates</creatorcontrib><title>Renal Effects of Coronary Artery Bypass Graft Surgery in Diabetic and Non-Diabetic Patients: A Study with Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C</title><title>Kidney & blood pressure research</title><addtitle>Kidney Blood Press Res</addtitle><description>Background/Aims: Cardiac surgery and diabetes are major causes of acute kidney injury (AKI). We aimed to investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C, as early biomarkers for prediction of AKI in diabetic and non-diabetic adult patients undergoing cardiac surgery. Methods: 15 non-diabetic and 15 diabetic adult patients undergoing cardiac surgery were enrolled. Peri-operative clinical and laboratory variables were recorded. Urinary NGAL, serum cystatin C, serum creatinine (Cre) and blood urea nitrogen (BUN) were evaluated. Results: AKI was detected in 4 patients in non-diabetic group and 12 patients in diabetic group. Urinary NGAL levels of diabetic and non-diabetic patients and serum cystatin C levels of diabetic patients exceed upper normal limits or cutoff values much earlier than BUN and Cre. cystatin C levels of non-diabetic patients remain unchanged. Cystatin C and NGAL levels of patients meeting AKI criteria and NGAL levels of patients not meeting AKI criteria exceeded upper normal limits or cut off values much earlier in than BUN and Cre. Conclusions: Measurement of cystatin C level in both diabetic and non-diabetic patients may reveal AKI earlier than NGAL and BUN. In diabetic patients, measurement of urinary NGAL and serum cystatin C levels may indicate AKI signs earlier than BUN and Cre.</description><subject>Acute kidney injury</subject><subject>Acute Kidney Injury - epidemiology</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute-Phase Proteins - urine</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia</subject><subject>Biomarkers</subject><subject>Blood Urea Nitrogen</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary artery bypass graft surgery</subject><subject>Creatinine - blood</subject><subject>Cystatin C</subject><subject>Cystatin C - urine</subject><subject>Diabetes</subject><subject>Diabetes Complications - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Function Tests</subject><subject>Lipocalin-2</subject><subject>Lipocalins - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophil gelatinase-associated lipocalin</subject><subject>Original Paper</subject><subject>Predictive Value of Tests</subject><subject>Proto-Oncogene Proteins - urine</subject><subject>Treatment Outcome</subject><subject>Urodynamics</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkkuP0zAQgCMEYh9w4I6QJS5wCNix4ybcumUpK6oFbdlzNLHHuy5pHGxHq_4s_iHugyIhTjMaff5mrJkse8HoO8bK-j2llMtK1PRRdspEwXPKBH-8y2kuaC1PsrMQVgkrKS2eZidFWfGCFdVp9usGe-jIpTGoYiDOkJnzrge_IVMfMYWLzQAhkLkHE8ly9Hfbou3JRwstRqsI9Jpcuz4_Fr5BtNjH8IFMyTKOekMebLwnt97uvNc4Ru-Ge9uROXaJ7SFgPg3BKQsRNVnYwSnoUo-teol-XJPZJsQtSmbPsicGuoDPD_E8u_10-X32OV98nV_NpotclZzGXKABpRmXkquacWhThhNVGFYUUJYohCwlKK4E1QpMqbkCLCqNE4oF54yfZ1d7r3awagZv12n4xoFtdgXn7xrw6bsdNlixKr2WTDAjJnVZ65ZXErVqoWpFLZPrzd41ePdzxBCbtQ0Kuw56dGNomJR1JShjdUJf_4Ou3OjTjhI14RVlsuZlot7uKeVdCB7NcUBGm-1NNMebSOyrg3Fs16iP5J8j-NvyB2y3ewS-XNzsFc2gTaJe_pc6dPkNECrHIA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Arun, Oguzhan</creator><creator>Celik, Gulperi</creator><creator>Oc, Bahar</creator><creator>Unlu, Ali</creator><creator>Celik, Jale Bengi</creator><creator>Oc, Mehmet</creator><creator>Duman, Ates</creator><general>S. 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We aimed to investigate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C, as early biomarkers for prediction of AKI in diabetic and non-diabetic adult patients undergoing cardiac surgery. Methods: 15 non-diabetic and 15 diabetic adult patients undergoing cardiac surgery were enrolled. Peri-operative clinical and laboratory variables were recorded. Urinary NGAL, serum cystatin C, serum creatinine (Cre) and blood urea nitrogen (BUN) were evaluated. Results: AKI was detected in 4 patients in non-diabetic group and 12 patients in diabetic group. Urinary NGAL levels of diabetic and non-diabetic patients and serum cystatin C levels of diabetic patients exceed upper normal limits or cutoff values much earlier than BUN and Cre. cystatin C levels of non-diabetic patients remain unchanged. Cystatin C and NGAL levels of patients meeting AKI criteria and NGAL levels of patients not meeting AKI criteria exceeded upper normal limits or cut off values much earlier in than BUN and Cre. Conclusions: Measurement of cystatin C level in both diabetic and non-diabetic patients may reveal AKI earlier than NGAL and BUN. In diabetic patients, measurement of urinary NGAL and serum cystatin C levels may indicate AKI signs earlier than BUN and Cre.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25832128</pmid><doi>10.1159/000368490</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute kidney injury Acute Kidney Injury - epidemiology Acute Kidney Injury - etiology Acute-Phase Proteins - urine Aged Aged, 80 and over Anesthesia Biomarkers Blood Urea Nitrogen Coronary Artery Bypass - adverse effects Coronary artery bypass graft surgery Creatinine - blood Cystatin C Cystatin C - urine Diabetes Diabetes Complications - metabolism Female Humans Kidney Function Tests Lipocalin-2 Lipocalins - urine Male Middle Aged Neutrophil gelatinase-associated lipocalin Original Paper Predictive Value of Tests Proto-Oncogene Proteins - urine Treatment Outcome Urodynamics |
| title | Renal Effects of Coronary Artery Bypass Graft Surgery in Diabetic and Non-Diabetic Patients: A Study with Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C |
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