Domino Oxidative Cyclization of 2-Amino­acetophenones for the One-Pot Synthesis of Tryptanthrin Derivatives

A new CuI/DMSO‐mediated oxidative domino process has been developed for the synthesis of tryptanthrin derivatives. This is the first example of the synthesis of tryptanthrin derivatives directly from 2‐aminoaryl methyl ketones and isatoic anhydrides through copper‐promoted oxidative functionalizatio...

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Bibliographic Details
Published in:European journal of organic chemistry 2015-12, Vol.2015 (36), p.8018-8022
Main Authors: Reddy, B. V. Subba, Reddy, D. Maheswara, Reddy, G. Niranjan, Reddy, M. Ramana, Reddy, V. Krishna
Format: Article
Language:English
Subjects:
1-b]­quinazolines
2-Aminoacetophenone
Indolo
Indolo[2,1‐b]­quinazolines
Isatoic anhydride
Nitrogen ­heterocycles
Synthetic methods
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Summary:A new CuI/DMSO‐mediated oxidative domino process has been developed for the synthesis of tryptanthrin derivatives. This is the first example of the synthesis of tryptanthrin derivatives directly from 2‐aminoaryl methyl ketones and isatoic anhydrides through copper‐promoted oxidative functionalization. A new DMSO/CuI‐catalysed oxidative domino process has been developed for the one‐pot synthesis of tryptanthrin derivatives.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201501079