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Domino Oxidative Cyclization of 2-Amino­acetophenones for the One-Pot Synthesis of Tryptanthrin Derivatives

A new CuI/DMSO‐mediated oxidative domino process has been developed for the synthesis of tryptanthrin derivatives. This is the first example of the synthesis of tryptanthrin derivatives directly from 2‐aminoaryl methyl ketones and isatoic anhydrides through copper‐promoted oxidative functionalizatio...

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Published in:European journal of organic chemistry 2015-12, Vol.2015 (36), p.8018-8022
Main Authors: Reddy, B. V. Subba, Reddy, D. Maheswara, Reddy, G. Niranjan, Reddy, M. Ramana, Reddy, V. Krishna
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description A new CuI/DMSO‐mediated oxidative domino process has been developed for the synthesis of tryptanthrin derivatives. This is the first example of the synthesis of tryptanthrin derivatives directly from 2‐aminoaryl methyl ketones and isatoic anhydrides through copper‐promoted oxidative functionalization. A new DMSO/CuI‐catalysed oxidative domino process has been developed for the one‐pot synthesis of tryptanthrin derivatives.
doi_str_mv 10.1002/ejoc.201501079
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source Wiley-Blackwell Read & Publish Collection
subjects 1-b]­quinazolines
2-Aminoacetophenone
Indolo
Indolo[2,1‐b]­quinazolines
Isatoic anhydride
Nitrogen ­heterocycles
Synthetic methods
title Domino Oxidative Cyclization of 2-Amino­acetophenones for the One-Pot Synthesis of Tryptanthrin Derivatives
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