Multidrug therapy of Mycobacterium avium subsp. avium infection in experimentally inoculated budgerigars (Melopsittacus undulatus)

The aim of the study was to determine whether the four-month experimental therapy of mycobacteriosis in budgerigars may cause a complete recovery. A group of nine budgerigars was infected with a Mycobacterium avium subsp. avium isolate with proven pathogenicity for budgerigars. Five weeks post-inocu...

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Bibliographic Details
Published in:Avian pathology 2015-11, Vol.44 (6), p.470-474
Main Authors: Ledwoń, A., Dolka, I., Dolka, B., Cegiełkowska, M., Czopowicz, M., Szeleszczuk, P.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - therapeutic use
Clarithromycin - therapeutic use
DNA fingerprints
Drug Therapy, Combination
Epidemiology
Ethambutol - therapeutic use
Female
Fluoroquinolones - therapeutic use
Galliformes - microbiology
Genetic diversity
Genotype & phenotype
Male
Melopsittacus - microbiology
Mycobacterium avium - drug effects
Salmonella
Tuberculosis, Avian - drug therapy
Tuberculosis, Avian - microbiology
Tuberculosis, Avian - pathology
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Summary:The aim of the study was to determine whether the four-month experimental therapy of mycobacteriosis in budgerigars may cause a complete recovery. A group of nine budgerigars was infected with a Mycobacterium avium subsp. avium isolate with proven pathogenicity for budgerigars. Five weeks post-inoculation, multidrug therapy was started. Another group comprising six birds received the same treatment but no infection, and the third group also comprising six birds was kept without infection or treatment as a control. The adopted antibiotic regimen included clarithromycin 61 mg/kg b.w., moxifloxacin 25 mg/kg b.w. and ethambutol 60 mg/kg b.w. administered by crop gavage every 12 h for 18 weeks. Despite a significant improvement in the condition of the infected, treated birds, the four-month therapy was not sufficient for the complete recovery of all.
ISSN:0307-9457
1465-3338
DOI:10.1080/03079457.2015.1086973