Thermodynamic implications of high Q10 of thermoTRP channels in living cells

The activity of thermo-transient receptor potential (TRP) channels is highly dependent on temperature, and thus thermo-TRP reactions have a high temperature coefficient Q10. In thermodynamics, a high value of Q10 indicates the existence of a large activation energy (i.e., a large enthalpy) over a sh...

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Bibliographic Details
Published in:BIOPHYSICS 2015, Vol.11, pp.33-38
Main Authors: Ito, Etsuro, Ikemoto, Yusuke, Yoshioka, Tohru
Format: Article
Language:English
Subjects:
enthalpy
entropy
Q10
temperature dependency
TRP channel
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Summary:The activity of thermo-transient receptor potential (TRP) channels is highly dependent on temperature, and thus thermo-TRP reactions have a high temperature coefficient Q10. In thermodynamics, a high value of Q10 indicates the existence of a large activation energy (i.e., a large enthalpy) over a short period during the transition process between the closed and open states of the channels. The Gibbs free energy equation shows that a large entropy is required to compensate for this large enthalpy and permit activation of the channels, suggesting a large conformational change of the channels. These large values of enthalpy and entropy seem to be a match for the values of the unfolding process of globular proteins. We outline these thermodynamic issues in thermo-TRPs.
ISSN:1349-2942
1349-2942
DOI:10.2142/biophysics.11.33