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Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery
Five CF3‐substituted 3‐azabicyclo[n.1.0]alkanes were synthesized by CuCl‐mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2. A mini‐library of CF3‐substituted bicyclic amines has been synthesized by using CF3CHN2.
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| Published in: | European journal of organic chemistry 2014-06, Vol.2014 (17), p.3592-3598 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4218-721bb04ffdf0c4c5a720f901a89a701109ac62667cae24da355078fd981a4bcb3 |
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| cites | cdi_FETCH-LOGICAL-c4218-721bb04ffdf0c4c5a720f901a89a701109ac62667cae24da355078fd981a4bcb3 |
| container_end_page | 3598 |
| container_issue | 17 |
| container_start_page | 3592 |
| container_title | European journal of organic chemistry |
| container_volume | 2014 |
| creator | Artamonov, Olexiy S. Slobodyanyuk, Evgeniy Y. Volochnyuk, Dmitriy M. Komarov, Igor V. Tolmachev, Andrey A. Mykhailiuk, Pavel K. |
| description | Five CF3‐substituted 3‐azabicyclo[n.1.0]alkanes were synthesized by CuCl‐mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2.
A mini‐library of CF3‐substituted bicyclic amines has been synthesized by using CF3CHN2. |
| doi_str_mv | 10.1002/ejoc.201402158 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1434-193X |
| ispartof | European journal of organic chemistry, 2014-06, Vol.2014 (17), p.3592-3598 |
| issn | 1434-193X 1099-0690 |
| language | eng |
| recordid | cdi_proquest_journals_1755831046 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Drug discovery Fluorine Nitrogen heterocycles Synthetic methods Trifluoromethyldiazomethane |
| title | Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery |
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