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Isolated abnormal strict morphology is not a contraindication for intrauterine insemination
Summary This study sought to investigate whether isolated abnormal strict morphology (
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| Published in: | Andrology (Oxford) 2015-11, Vol.3 (6), p.1088-1093 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c4638-710cb8e9cca2153cd44d2d29debace4283c1eb0968fac8fd9317b1c82bb292253 |
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| cites | cdi_FETCH-LOGICAL-c4638-710cb8e9cca2153cd44d2d29debace4283c1eb0968fac8fd9317b1c82bb292253 |
| container_end_page | 1093 |
| container_issue | 6 |
| container_start_page | 1088 |
| container_title | Andrology (Oxford) |
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| creator | Lockwood, G. M. Deveneau, N. E. Shridharani, A. N. Strawn, E. Y. Sandlow, J. I. |
| description | Summary
This study sought to investigate whether isolated abnormal strict morphology ( |
| doi_str_mv | 10.1111/andr.12098 |
| format | article |
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This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0–1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded.</description><identifier>ISSN: 2047-2919</identifier><identifier>EISSN: 2047-2927</identifier><identifier>DOI: 10.1111/andr.12098</identifier><identifier>PMID: 26384603</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Artificial insemination ; assisted reproductive technology ; Cattle ; Female ; Humans ; Infertility, Male - pathology ; Infertility, Male - physiopathology ; Infertility, Male - therapy ; Insemination, Artificial, Homologous ; intrauterine insemination ; Male ; male infertility ; Morphology ; Predictive Value of Tests ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Risk Factors ; Semen Analysis ; Spermatozoa - pathology ; strict sperm morphology ; teratozoospermia ; Treatment Outcome</subject><ispartof>Andrology (Oxford), 2015-11, Vol.3 (6), p.1088-1093</ispartof><rights>2015 American Society of Andrology and European Academy of Andrology</rights><rights>2015 American Society of Andrology and European Academy of Andrology.</rights><rights>Andrology © 2015 American Society of Andrology and European Academy of Andrology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4638-710cb8e9cca2153cd44d2d29debace4283c1eb0968fac8fd9317b1c82bb292253</citedby><cites>FETCH-LOGICAL-c4638-710cb8e9cca2153cd44d2d29debace4283c1eb0968fac8fd9317b1c82bb292253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26384603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lockwood, G. M.</creatorcontrib><creatorcontrib>Deveneau, N. E.</creatorcontrib><creatorcontrib>Shridharani, A. N.</creatorcontrib><creatorcontrib>Strawn, E. Y.</creatorcontrib><creatorcontrib>Sandlow, J. I.</creatorcontrib><title>Isolated abnormal strict morphology is not a contraindication for intrauterine insemination</title><title>Andrology (Oxford)</title><addtitle>Andrology</addtitle><description>Summary
This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0–1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded.</description><subject>Adult</subject><subject>Artificial insemination</subject><subject>assisted reproductive technology</subject><subject>Cattle</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility, Male - pathology</subject><subject>Infertility, Male - physiopathology</subject><subject>Infertility, Male - therapy</subject><subject>Insemination, Artificial, Homologous</subject><subject>intrauterine insemination</subject><subject>Male</subject><subject>male infertility</subject><subject>Morphology</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Semen Analysis</subject><subject>Spermatozoa - pathology</subject><subject>strict sperm morphology</subject><subject>teratozoospermia</subject><subject>Treatment Outcome</subject><issn>2047-2919</issn><issn>2047-2927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobszd-AMk4J3QmaRdm1yO-TUYCqJXXpQ0STWjTWaSIvv3puvcpYfAOcl5eE_OC8AlRjMc45Yb6WaYIEZPwJigrEgII8XpscZsBKbeb1AM2h9yDkYkT2mWo3QMPlbeNjwoCXllrGt5A31wWgTYWrf9so393EHtobEBciisCY5rI7XgQVsDa-ug7t-6oJw2Kl68arXZdy_AWc0br6aHPAHvD_dvy6dk_fK4Wi7WicjiP5ICI1FRxYTgBM9TIbNMEkmYVBUXKiM0FVhViOW05oLWkqW4qLCgpKriqmSeTsD1oLt19rtTPpQb2zkTR5a4mBeI5izuOgE3AyWc9d6putw63XK3KzEqeyvL3spyb2WErw6SXdUqeUT_jIsAHoAf3ajdP1Ll4vnudRD9BT_4gAU</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Lockwood, G. M.</creator><creator>Deveneau, N. E.</creator><creator>Shridharani, A. N.</creator><creator>Strawn, E. Y.</creator><creator>Sandlow, J. I.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201511</creationdate><title>Isolated abnormal strict morphology is not a contraindication for intrauterine insemination</title><author>Lockwood, G. M. ; Deveneau, N. E. ; Shridharani, A. N. ; Strawn, E. Y. ; Sandlow, J. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4638-710cb8e9cca2153cd44d2d29debace4283c1eb0968fac8fd9317b1c82bb292253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Artificial insemination</topic><topic>assisted reproductive technology</topic><topic>Cattle</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility, Male - pathology</topic><topic>Infertility, Male - physiopathology</topic><topic>Infertility, Male - therapy</topic><topic>Insemination, Artificial, Homologous</topic><topic>intrauterine insemination</topic><topic>Male</topic><topic>male infertility</topic><topic>Morphology</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Semen Analysis</topic><topic>Spermatozoa - pathology</topic><topic>strict sperm morphology</topic><topic>teratozoospermia</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lockwood, G. M.</creatorcontrib><creatorcontrib>Deveneau, N. E.</creatorcontrib><creatorcontrib>Shridharani, A. N.</creatorcontrib><creatorcontrib>Strawn, E. Y.</creatorcontrib><creatorcontrib>Sandlow, J. I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Andrology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lockwood, G. M.</au><au>Deveneau, N. E.</au><au>Shridharani, A. N.</au><au>Strawn, E. Y.</au><au>Sandlow, J. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolated abnormal strict morphology is not a contraindication for intrauterine insemination</atitle><jtitle>Andrology (Oxford)</jtitle><addtitle>Andrology</addtitle><date>2015-11</date><risdate>2015</risdate><volume>3</volume><issue>6</issue><spage>1088</spage><epage>1093</epage><pages>1088-1093</pages><issn>2047-2919</issn><eissn>2047-2927</eissn><abstract>Summary
This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0–1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26384603</pmid><doi>10.1111/andr.12098</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Artificial insemination assisted reproductive technology Cattle Female Humans Infertility, Male - pathology Infertility, Male - physiopathology Infertility, Male - therapy Insemination, Artificial, Homologous intrauterine insemination Male male infertility Morphology Predictive Value of Tests Pregnancy Pregnancy Rate Retrospective Studies Risk Factors Semen Analysis Spermatozoa - pathology strict sperm morphology teratozoospermia Treatment Outcome |
| title | Isolated abnormal strict morphology is not a contraindication for intrauterine insemination |
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