A Systematic Study on the Synthesis of n-Butyl Substituted 8-Aminoquinolines

A systematic study on the synthesis of 8‐aminoquinoline derivatives with an n‐butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner–von Miller variation were used to obtain most of the quinoline ring except for the 2‐butyl‐8‐aminoquinolines and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry 2016-01, Vol.53 (1), p.263-270
Main Authors: Koseoglu, Ahmet, Gul, Turan, Acar, Ali Ersin
Format: Article
Language:English
Subjects:
Spectrum analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A systematic study on the synthesis of 8‐aminoquinoline derivatives with an n‐butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner–von Miller variation were used to obtain most of the quinoline ring except for the 2‐butyl‐8‐aminoquinolines and 4‐butyl‐8‐aminoquinolines where the commercially available methylquinoline derivatives were used as precursors. The structures of the synthesized compounds were characterized by FTIR, 1H‐NMR, COSY, 13C‐NMR and HRMS spectra.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2399