Anti-Apoptosis and Cell Survival Gene Expression Profile in LAD2 Cells

The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB76-AB76
Main Authors: Kirshenbaum, Arnold S., MD, FAAAAI, Leerkes, Maarten, PhD, Desai, Avanti, MS, Metcalfe, Dean D., MD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Apoptosis
Cell cycle
Gene expression
Kinases
Mutation
Online Access:Get full text
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Description
Summary:The observation that LAD2 cells survive without rhSCF but require rhSCF for growth, suggests that NF-kappaB activation, reduced cell cycle inhibition, decreased p53-induced apoptosis and stable telomere lengthening may contribute to LAD2 cell immortalization.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.256