CXCR4/SDF-1 Axis Promotes EMT Mediated Fibrosis in Eosinophilic Esophagitis (EoE)

Furthermore, we observed that the levels of mesenchymal marker N-cadherin, TGF-β and Vimentin are induced and epithelial marker E-cadherin is reduced in the esophagus of IL-13 transgenic mice exposed to DOX food compared to no DOX treated mice.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB228-AB228
Main Authors: Mahadevappa, Chandrashekara Puthanapura, PhD, Venkateshaiah, Sathisha Upparahalli, PhD, Manohar, Murli, Mishra, Anil, PhD, FAAAAI
Format: Article
Language:English
Subjects:
Allergy and Immunology
Rodents
Transgenic animals
Online Access:Get full text
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Description
Summary:Furthermore, we observed that the levels of mesenchymal marker N-cadherin, TGF-β and Vimentin are induced and epithelial marker E-cadherin is reduced in the esophagus of IL-13 transgenic mice exposed to DOX food compared to no DOX treated mice.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.880