Impairment of Autophagy in Pulmonary CD11c+ Cells Induces Corticosteroid-Unresponsive Airway Hyperreactivity

Adoptive transfer of bone-marrow derived CD11c+ cells from ATG5-/- but not WT mice is sufficient to mediate Th17-dependent neutrophilic asthma in WT recipients.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.AB410-AB410
Main Authors: Maazi, Hadi, Dr, Suzuki, Yuzo, Dr, Khoo, Bryant, Mr, Soroosh, Pejman, Dr, Jung, Jae U., Dr, Akbari, Omid, Prof
Format: Article
Language:English
Subjects:
Allergy and Immunology
Asthma
Autophagy
Inflammation
Pathogenesis
Rodents
Online Access:Get full text
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Description
Summary:Adoptive transfer of bone-marrow derived CD11c+ cells from ATG5-/- but not WT mice is sufficient to mediate Th17-dependent neutrophilic asthma in WT recipients.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.12.1270