Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: a pilot cross-over study

A pilot cross-over study assessed the acute effects on blood pressure and plasma biomarkers associated with consumption of a 300 ml anthocyanin-rich fruit juice, provided in differing dose-intervals. Young adults (n = 6) and older adults (n = 7) received in random order, either a single 300 ml dose...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2016-01, Vol.67 (1), p.47-52
Main Authors: Kent, Katherine, Charlton, Karen E., Jenner, Andrew, Roodenrys, Steven
Format: Article
Language:English
Subjects:
Acute
Adult
Aged
Aged, 80 and over
anthocyanins
Anthocyanins - administration & dosage
Anthocyanins - pharmacology
Biomarkers
Biomarkers - blood
Blood pressure
Blood Pressure - drug effects
cherry juice
cross-over
Cross-Over Studies
dose
Flavonoids - pharmacology
Food science
Fruit - chemistry
Fruit and Vegetable Juices
Fruit juices
Humans
Hypertension
Metabolites
Phenols - blood
Pigments
Pilot Projects
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Prunus - chemistry
Young Adult
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Summary:A pilot cross-over study assessed the acute effects on blood pressure and plasma biomarkers associated with consumption of a 300 ml anthocyanin-rich fruit juice, provided in differing dose-intervals. Young adults (n = 6) and older adults (n = 7) received in random order, either a single 300 ml dose or 3 × 100 ml doses of high-flavonoid cherry juice provided at 0, 1 and 2 h. Blood pressure and plasma levels of phenolic metabolites were measured at 0, 2 and 6 h.The single 300 ml dose of cherry juice resulted in a significant reduction in systolic (p = 0.002), and diastolic blood pressure (p = 0.008) and heart-rate (p = 0.033) 2 h after consumption, before returning to baseline levels at 6 h post-consumption. The 3 × 100 ml dose provided over 2 h did not result in significant blood pressure reductions. Plasma phenolic metabolites increased at 2 and 6 h; however, fluctuations were higher after the single 300 ml dose in older adults. These findings have implications for design of intervention studies that investigate vascular effects associated with flavonoid-rich foods.
ISSN:0963-7486
1465-3478
DOI:10.3109/09637486.2015.1121472