Metabolomics Studies Show Dose-Dependent Toxicity Induced by SiO2 Nanoparticles in MRC-5 Human Fetal Lung Fibroblasts

Metabolomics measures a comprehensive range of metabolites and is applied here to understand cellular toxicity of nano‐SiO2. Silica nanoparticles are assessed for their effects on MRC‐5 lung fibroblasts and initial investigations reveal no significant alterations in cell viability and morphology. Fu...

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Bibliographic Details
Published in:Advanced healthcare materials 2012-11, Vol.1 (6), p.779-784
Main Authors: Huang, Shao-Min, Zuo, Xinbing, Li, Jasmine Jia'En, Li, Sam Fong Yau, Bay, Boon Huat, Ong, Choon Nam
Format: Article
Language:English
Subjects:
metabolomics
MRC-5 fibroblasts
silica nanoparticles
toxicity
vacuoles
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Summary:Metabolomics measures a comprehensive range of metabolites and is applied here to understand cellular toxicity of nano‐SiO2. Silica nanoparticles are assessed for their effects on MRC‐5 lung fibroblasts and initial investigations reveal no significant alterations in cell viability and morphology. Further metabolomic analysis reveals dose‐dependent alterations in cellular metabolism due to nano‐SiO2 exposure. This methodology may be a potentially useful analytical platform to investigate nanotoxicity.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200114