A Fast and Highly Efficient Protocol for Reductive Amination of Aromatic Aldehydes Using NaBH4 and Isoxazole Amines in an Ionic Liquid Medium

Reductive amination of aromatic aldehydes using NaBH4 and isoxazole amines is carried out in a Bronsted acidic ionic liquid 1 -methylimidazolium tetrafluoroborate [（HMIm）BF4]. The ionic liquid plays dual roles of solvent as well as catalyst for the efficixcellent yields without any undesired side pr...

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Bibliographic Details
Published in:Chinese journal of chemistry 2011-04, Vol.29 (4), p.769-772
Main Author: Eligeti, Rajanarendar Atthunuri, Siva Rami Reddy Samala, Raju Shaik, Firoz Pasha Govardhan Reddy
Format: Article
Language:English
Subjects:
1-methylimidazolium tetrafluoroborate
green chemistry reductive amination
ionic liquid
isoxazole amine
四氟硼酸盐
异恶唑
甲基咪唑
硼氢化钠
离子液体
芳香醛
还原胺化
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Summary:Reductive amination of aromatic aldehydes using NaBH4 and isoxazole amines is carried out in a Bronsted acidic ionic liquid 1 -methylimidazolium tetrafluoroborate [（HMIm）BF4]. The ionic liquid plays dual roles of solvent as well as catalyst for the efficixcellent yields without any undesired side product formation. The newly synthesized compoundsent transformation of aromatic aldehydes to heterocyclic substituted amines in e （3, 6 and 7） were characterized by IR, 1H NMR and mass spectral techniques.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201190155