LiBr as an Efficient Catalyst for One-pot Synthesis of Hantzsch 1,4-Dihydropyridines under Mild Conditions

A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridines has been accomplished via lithium bromide-catalyzed Hantzsch three-component condensation reaction of an aldehyde, α,β-ketoester and ammonium acetate in acetonitrile at room temperature in good to excellent yields. The pre...

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Bibliographic Details
Published in:Chinese journal of chemistry 2011, Vol.29 (1), p.118-122
Main Author: Yadav, D. K. Patel, R. Srivastava, V. P. Watal, G. Yadav, L. D. S
Format: Article
Language:English
Subjects:
1,4‐dihydropyridines
4-dihydropyridines
cyclization
Hantzsch reaction
lithium bromide
multicomponent reactions
one-pot procedure
一锅合成
三组分
二氢吡啶
杂环醛
温和条件
溴化锂
缩合反应
高效催化剂
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Summary:A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridines has been accomplished via lithium bromide-catalyzed Hantzsch three-component condensation reaction of an aldehyde, α,β-ketoester and ammonium acetate in acetonitrile at room temperature in good to excellent yields. The present protocol is applicable to wide range of substrates including aliphatic, aromatic and heterocyclic aldehydes affording 1,4-dihydropyridines.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201190036