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Evaluation of pedometry as a patient-centered outcome in patients undergoing hematopoietic cell transplant (HCT): a comparison of pedometry and patient reports of symptoms, health, and quality of life

Aims We evaluated pedometry as a novel patient-cen-tered outcome because it enables passive continuous assessment of activity and may provide information about the consequences of symptomatic toxicity complementary to self-report. Methods Adult patients undergoing hematopoietic cell transplant (HCT)...

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Published in:Quality of life research 2016-03, Vol.25 (3), p.535-546
Main Authors: Bennett, Antonia V., Reeve, Bryce B., Basch, Ethan M., Mitchell, Sandra A., Meeneghan, Mathew, Battaglini, Claudio L., Smith-Ryan, E., Phillips, Brett, Shea, Thomas C., Wood, William A.
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cited_by cdi_FETCH-LOGICAL-c573t-79ae8cc906405bc42524ec0cb66c3f548b2de9bb61155c50c634602d6466fea83
cites cdi_FETCH-LOGICAL-c573t-79ae8cc906405bc42524ec0cb66c3f548b2de9bb61155c50c634602d6466fea83
container_end_page 546
container_issue 3
container_start_page 535
container_title Quality of life research
container_volume 25
creator Bennett, Antonia V.
Reeve, Bryce B.
Basch, Ethan M.
Mitchell, Sandra A.
Meeneghan, Mathew
Battaglini, Claudio L.
Smith-Ryan, E.
Phillips, Brett
Shea, Thomas C.
Wood, William A.
description Aims We evaluated pedometry as a novel patient-cen-tered outcome because it enables passive continuous assessment of activity and may provide information about the consequences of symptomatic toxicity complementary to self-report. Methods Adult patients undergoing hematopoietic cell transplant (HCT) wore pedometers and completed PRO assessments during transplant hospitalization (4 weeks) and 4 weeks post-discharge. Patient reports of symptomatic treatment toxicities (single items from PROCTCAE, http://healthcaredelivery. cancer.gov/pro-ctcae) and symptoms, physical health, mental health, and quality of life (PROMIS® Global-10, http://nih.promis.org), assessed weekly with 7-day recall on Likert scales, were compared individually with pedometry data, summarized as average daily steps per week, using linear mixed models. Results Thirty-two patients [mean age 55 (SD = 14), 63 % male, 84 % white, 56 % autologous, 43 % allogeneic] completed a mean 4.6 (SD = 1.5, range 1-8) evaluable assessments. Regression model coefficients (β) indicated within-person decrements in average daily steps were associated with increases in pain (β = –852; 852 fewer steps per unit increase in pain score, p < 0.001), fatigue (β = –886, p < 0.001), vomiting (β = –518, p < 0.01), shaking/chills (β = –587, p < 0.01), diarrhea (β = –719, p < 0.001), shortness of breath (β = –1018, p < 0.05), reduction in carrying out social activities (β = 705, p < 0.01) or physical activities (β = 618, p < 0.01), and global physical health (β = 101, p < 0.001), but not global mental health or quality of life. Conclusions In this small sample of HCT recipients, more severe symptoms, impaired physical health, and restrictions in the performance of usual daily activities were associated with statistically significant decrements in objectively measured daily steps. Pedometry may be a valuable outcome measure and validation anchor in clinical research.
doi_str_mv 10.1007/s11136-015-1179-0
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Methods Adult patients undergoing hematopoietic cell transplant (HCT) wore pedometers and completed PRO assessments during transplant hospitalization (4 weeks) and 4 weeks post-discharge. Patient reports of symptomatic treatment toxicities (single items from PROCTCAE, http://healthcaredelivery. cancer.gov/pro-ctcae) and symptoms, physical health, mental health, and quality of life (PROMIS® Global-10, http://nih.promis.org), assessed weekly with 7-day recall on Likert scales, were compared individually with pedometry data, summarized as average daily steps per week, using linear mixed models. Results Thirty-two patients [mean age 55 (SD = 14), 63 % male, 84 % white, 56 % autologous, 43 % allogeneic] completed a mean 4.6 (SD = 1.5, range 1-8) evaluable assessments. Regression model coefficients (β) indicated within-person decrements in average daily steps were associated with increases in pain (β = –852; 852 fewer steps per unit increase in pain score, p < 0.001), fatigue (β = –886, p < 0.001), vomiting (β = –518, p < 0.01), shaking/chills (β = –587, p < 0.01), diarrhea (β = –719, p < 0.001), shortness of breath (β = –1018, p < 0.05), reduction in carrying out social activities (β = 705, p < 0.01) or physical activities (β = 618, p < 0.01), and global physical health (β = 101, p < 0.001), but not global mental health or quality of life. Conclusions In this small sample of HCT recipients, more severe symptoms, impaired physical health, and restrictions in the performance of usual daily activities were associated with statistically significant decrements in objectively measured daily steps. Pedometry may be a valuable outcome measure and validation anchor in clinical research.]]></description><identifier>ISSN: 0962-9343</identifier><identifier>EISSN: 1573-2649</identifier><identifier>DOI: 10.1007/s11136-015-1179-0</identifier><identifier>PMID: 26577763</identifier><language>eng</language><publisher>Cham: Springer</publisher><subject>Accelerometry ; Activities of Daily Living ; Adolescent ; Adult ; Aged ; Cancer therapies ; Chemotherapy ; Cross-Sectional Studies ; Disease ; Exercise ; Fatigue ; Feasibility studies ; Female ; Fitness training programs ; Follow-Up Studies ; Health outcomes ; Health Status Indicators ; Hematopoietic Stem Cell Transplantation - psychology ; Humans ; Literacy ; Male ; Medicine ; Medicine &amp; Public Health ; Mental health ; Middle Aged ; Missing data ; Motor Activity ; Oncology ; Patient Outcome Assessment ; Patients ; Physical fitness ; Physical health ; Public Health ; Quality of Life ; Quality of Life Research ; Radiation ; Self Report ; Sociology ; SPECIAL SECTION: PROS IN NON-STANDARD SETTINGS (BY INVITATION ONLY) ; Stem cell transplantation ; Stem cells ; Symptom severity ; Symptoms ; Toxicity ; Transplants &amp; implants ; Vomiting ; Young Adult</subject><ispartof>Quality of life research, 2016-03, Vol.25 (3), p.535-546</ispartof><rights>Springer International Publishing 2016</rights><rights>Springer International Publishing Switzerland 2015</rights><rights>Springer International Publishing Switzerland 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-79ae8cc906405bc42524ec0cb66c3f548b2de9bb61155c50c634602d6466fea83</citedby><cites>FETCH-LOGICAL-c573t-79ae8cc906405bc42524ec0cb66c3f548b2de9bb61155c50c634602d6466fea83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1771299086/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1771299086?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,11688,27924,27925,36060,44363,58238,58471,74895</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26577763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bennett, Antonia V.</creatorcontrib><creatorcontrib>Reeve, Bryce B.</creatorcontrib><creatorcontrib>Basch, Ethan M.</creatorcontrib><creatorcontrib>Mitchell, Sandra A.</creatorcontrib><creatorcontrib>Meeneghan, Mathew</creatorcontrib><creatorcontrib>Battaglini, Claudio L.</creatorcontrib><creatorcontrib>Smith-Ryan, E.</creatorcontrib><creatorcontrib>Phillips, Brett</creatorcontrib><creatorcontrib>Shea, Thomas C.</creatorcontrib><creatorcontrib>Wood, William A.</creatorcontrib><title>Evaluation of pedometry as a patient-centered outcome in patients undergoing hematopoietic cell transplant (HCT): a comparison of pedometry and patient reports of symptoms, health, and quality of life</title><title>Quality of life research</title><addtitle>Qual Life Res</addtitle><addtitle>Qual Life Res</addtitle><description><![CDATA[Aims We evaluated pedometry as a novel patient-cen-tered outcome because it enables passive continuous assessment of activity and may provide information about the consequences of symptomatic toxicity complementary to self-report. Methods Adult patients undergoing hematopoietic cell transplant (HCT) wore pedometers and completed PRO assessments during transplant hospitalization (4 weeks) and 4 weeks post-discharge. Patient reports of symptomatic treatment toxicities (single items from PROCTCAE, http://healthcaredelivery. cancer.gov/pro-ctcae) and symptoms, physical health, mental health, and quality of life (PROMIS® Global-10, http://nih.promis.org), assessed weekly with 7-day recall on Likert scales, were compared individually with pedometry data, summarized as average daily steps per week, using linear mixed models. Results Thirty-two patients [mean age 55 (SD = 14), 63 % male, 84 % white, 56 % autologous, 43 % allogeneic] completed a mean 4.6 (SD = 1.5, range 1-8) evaluable assessments. Regression model coefficients (β) indicated within-person decrements in average daily steps were associated with increases in pain (β = –852; 852 fewer steps per unit increase in pain score, p < 0.001), fatigue (β = –886, p < 0.001), vomiting (β = –518, p < 0.01), shaking/chills (β = –587, p < 0.01), diarrhea (β = –719, p < 0.001), shortness of breath (β = –1018, p < 0.05), reduction in carrying out social activities (β = 705, p < 0.01) or physical activities (β = 618, p < 0.01), and global physical health (β = 101, p < 0.001), but not global mental health or quality of life. Conclusions In this small sample of HCT recipients, more severe symptoms, impaired physical health, and restrictions in the performance of usual daily activities were associated with statistically significant decrements in objectively measured daily steps. Pedometry may be a valuable outcome measure and validation anchor in clinical research.]]></description><subject>Accelerometry</subject><subject>Activities of Daily Living</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Cross-Sectional Studies</subject><subject>Disease</subject><subject>Exercise</subject><subject>Fatigue</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>Fitness training programs</subject><subject>Follow-Up Studies</subject><subject>Health outcomes</subject><subject>Health Status Indicators</subject><subject>Hematopoietic Stem Cell Transplantation - psychology</subject><subject>Humans</subject><subject>Literacy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Missing data</subject><subject>Motor Activity</subject><subject>Oncology</subject><subject>Patient Outcome Assessment</subject><subject>Patients</subject><subject>Physical fitness</subject><subject>Physical health</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Quality of Life Research</subject><subject>Radiation</subject><subject>Self Report</subject><subject>Sociology</subject><subject>SPECIAL SECTION: PROS IN NON-STANDARD SETTINGS (BY INVITATION ONLY)</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Symptom severity</subject><subject>Symptoms</subject><subject>Toxicity</subject><subject>Transplants &amp; 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Reeve, Bryce B. ; Basch, Ethan M. ; Mitchell, Sandra A. ; Meeneghan, Mathew ; Battaglini, Claudio L. ; Smith-Ryan, E. ; Phillips, Brett ; Shea, Thomas C. ; Wood, William A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-79ae8cc906405bc42524ec0cb66c3f548b2de9bb61155c50c634602d6466fea83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Accelerometry</topic><topic>Activities of Daily Living</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Cross-Sectional Studies</topic><topic>Disease</topic><topic>Exercise</topic><topic>Fatigue</topic><topic>Feasibility studies</topic><topic>Female</topic><topic>Fitness training programs</topic><topic>Follow-Up Studies</topic><topic>Health outcomes</topic><topic>Health Status Indicators</topic><topic>Hematopoietic Stem Cell Transplantation - psychology</topic><topic>Humans</topic><topic>Literacy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; 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Methods Adult patients undergoing hematopoietic cell transplant (HCT) wore pedometers and completed PRO assessments during transplant hospitalization (4 weeks) and 4 weeks post-discharge. Patient reports of symptomatic treatment toxicities (single items from PROCTCAE, http://healthcaredelivery. cancer.gov/pro-ctcae) and symptoms, physical health, mental health, and quality of life (PROMIS® Global-10, http://nih.promis.org), assessed weekly with 7-day recall on Likert scales, were compared individually with pedometry data, summarized as average daily steps per week, using linear mixed models. Results Thirty-two patients [mean age 55 (SD = 14), 63 % male, 84 % white, 56 % autologous, 43 % allogeneic] completed a mean 4.6 (SD = 1.5, range 1-8) evaluable assessments. Regression model coefficients (β) indicated within-person decrements in average daily steps were associated with increases in pain (β = –852; 852 fewer steps per unit increase in pain score, p < 0.001), fatigue (β = –886, p < 0.001), vomiting (β = –518, p < 0.01), shaking/chills (β = –587, p < 0.01), diarrhea (β = –719, p < 0.001), shortness of breath (β = –1018, p < 0.05), reduction in carrying out social activities (β = 705, p < 0.01) or physical activities (β = 618, p < 0.01), and global physical health (β = 101, p < 0.001), but not global mental health or quality of life. Conclusions In this small sample of HCT recipients, more severe symptoms, impaired physical health, and restrictions in the performance of usual daily activities were associated with statistically significant decrements in objectively measured daily steps. Pedometry may be a valuable outcome measure and validation anchor in clinical research.]]></abstract><cop>Cham</cop><pub>Springer</pub><pmid>26577763</pmid><doi>10.1007/s11136-015-1179-0</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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subjects Accelerometry
Activities of Daily Living
Adolescent
Adult
Aged
Cancer therapies
Chemotherapy
Cross-Sectional Studies
Disease
Exercise
Fatigue
Feasibility studies
Female
Fitness training programs
Follow-Up Studies
Health outcomes
Health Status Indicators
Hematopoietic Stem Cell Transplantation - psychology
Humans
Literacy
Male
Medicine
Medicine & Public Health
Mental health
Middle Aged
Missing data
Motor Activity
Oncology
Patient Outcome Assessment
Patients
Physical fitness
Physical health
Public Health
Quality of Life
Quality of Life Research
Radiation
Self Report
Sociology
SPECIAL SECTION: PROS IN NON-STANDARD SETTINGS (BY INVITATION ONLY)
Stem cell transplantation
Stem cells
Symptom severity
Symptoms
Toxicity
Transplants & implants
Vomiting
Young Adult
title Evaluation of pedometry as a patient-centered outcome in patients undergoing hematopoietic cell transplant (HCT): a comparison of pedometry and patient reports of symptoms, health, and quality of life
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