Prediction of protein conformational mobility with validation using small-angle X-ray scattering

A “coarse-grained” model of protein conformational mobility is presented. The conformational paths in five proteins, predicted using the model, are compared with those obtained by the nearest-neighbor method basing on the small-angle X-ray scattering data. The sequences of conformations evaluated wi...

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Bibliographic Details
Published in:Biophysics (Oxford) 2015-11, Vol.60 (6), p.886-892
Main Authors: Knyazev, S. N., Kalyakin, V. Yu, Deryabin, I. N., Fedorov, B. A., Smirnov, A. V., Stepanov, E. O., Porozov, Yu. B.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Molecular Biophysics
Physics
Physics and Astronomy
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Summary:A “coarse-grained” model of protein conformational mobility is presented. The conformational paths in five proteins, predicted using the model, are compared with those obtained by the nearest-neighbor method basing on the small-angle X-ray scattering data. The sequences of conformations evaluated with the help of these two approaches have been shown for all proteins under consideration to coincide well; yet there are exceptions, their causes having to be considered for each protein separately.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350915060147