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Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits
The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties. To better understand the role of the kidney in HDL catabolism, here we characterized HDL subclasses and the catabolic rates of apo A-I in a rabbit model of proteinuria....
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| Published in: | Lipids 2016-03, Vol.51 (3), p.311-320 |
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| Main Authors: | , , , , , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373 |
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| cites | cdi_FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373 |
| container_end_page | 320 |
| container_issue | 3 |
| container_start_page | 311 |
| container_title | Lipids |
| container_volume | 51 |
| creator | López-Olmos, Victoria Carreón-Torres, Elizabeth Luna-Luna, María Flores-Castillo, Cristobal Martínez-Ramírez, Miriam Bautista-Pérez, Rocío Franco, Martha Sandoval-Zárate, Julio Roldán, Francisco-Javier Aranda-Fraustro, Alberto Soria-Castro, Elizabeth Muñoz-Vega, Mónica Fragoso, José-Manuel Vargas-Alarcón, Gilberto Pérez-Méndez, Oscar |
| description | The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties. To better understand the role of the kidney in HDL catabolism, here we characterized HDL subclasses and the catabolic rates of apo A-I in a rabbit model of proteinuria. Proteinuria was induced by intravenous administration of doxorubicin in New Zealand white rabbits (
n
= 10). HDL size and HDL subclass lipids were assessed by electrophoresis of the isolated lipoproteins. The catabolic rate of HDL-apo A-I was evaluated by exogenous radiolabelling with iodine-131. Doxorubicin induced significant proteinuria after 4 weeks (4.47 ± 0.55 vs. 0.30 ± 0.02 g/L of protein in urine,
P
|
| doi_str_mv | 10.1007/s11745-016-4120-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1771403422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3974638251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373</originalsourceid><addsrcrecordid>eNqFkF1rFDEUhoModlv9Ad5IwOvUnJnMZHO57FY7sGjxg4I3IR9n3JRtZk1mqPUX-LPNMlW8Ea_CCe_znMNLyAvg58C5fJ0BpGgYh5YJqDhrH5EFNM2SqZrLx2TBeSWYqDickNOcb8oIQjVPyUnVyiXItlmQn110CU1GTy83W_ox_EBqoqcXcWeiK7-rw0BXrKNrMxo77IOjH8yIma4S0lXOgwtl9PQ6jDu6Gb4PabLBhci66Kcjf5WGEUOcUjA0RPoO7-gXNPvjjutdGLHorA1jfkae9Gaf8fnDe0Y-v7n4tL5k2_dvu_Vqy5xQHBhKJ0BKAarirvWt6iXH3qKV3ioB6G2j-mWlWtP3ftkIcF61XElneqlsLesz8mr2HtLwbcI86pthSrGs1MULgteiqkoK5pRLQ84Je31I4dakew1cH7vXc_e6dK-P3eu2MC8fzJO9Rf-H-F12Ccg5cBf2eP9_o952VxteAxSymslcoPgV019H__OeXzVNnrk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771403422</pqid></control><display><type>article</type><title>Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits</title><source>Wiley</source><source>Springer Journals</source><creator>López-Olmos, Victoria ; Carreón-Torres, Elizabeth ; Luna-Luna, María ; Flores-Castillo, Cristobal ; Martínez-Ramírez, Miriam ; Bautista-Pérez, Rocío ; Franco, Martha ; Sandoval-Zárate, Julio ; Roldán, Francisco-Javier ; Aranda-Fraustro, Alberto ; Soria-Castro, Elizabeth ; Muñoz-Vega, Mónica ; Fragoso, José-Manuel ; Vargas-Alarcón, Gilberto ; Pérez-Méndez, Oscar</creator><creatorcontrib>López-Olmos, Victoria ; Carreón-Torres, Elizabeth ; Luna-Luna, María ; Flores-Castillo, Cristobal ; Martínez-Ramírez, Miriam ; Bautista-Pérez, Rocío ; Franco, Martha ; Sandoval-Zárate, Julio ; Roldán, Francisco-Javier ; Aranda-Fraustro, Alberto ; Soria-Castro, Elizabeth ; Muñoz-Vega, Mónica ; Fragoso, José-Manuel ; Vargas-Alarcón, Gilberto ; Pérez-Méndez, Oscar</creatorcontrib><description>The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties. To better understand the role of the kidney in HDL catabolism, here we characterized HDL subclasses and the catabolic rates of apo A-I in a rabbit model of proteinuria. Proteinuria was induced by intravenous administration of doxorubicin in New Zealand white rabbits (
n
= 10). HDL size and HDL subclass lipids were assessed by electrophoresis of the isolated lipoproteins. The catabolic rate of HDL-apo A-I was evaluated by exogenous radiolabelling with iodine-131. Doxorubicin induced significant proteinuria after 4 weeks (4.47 ± 0.55 vs. 0.30 ± 0.02 g/L of protein in urine,
P
< 0.001) associated with increased uremia, creatininemia, and cardiotoxicity. Large HDL2b augmented significantly during proteinuria, whereas small HDL3b and HDL3c decreased compared to basal conditions. HDL2b, HDL2a, and HDL3a subclasses were enriched with triacylglycerols in proteinuric animals as determined by the triacylglycerol-to-phospholipid ratio; the cholesterol content in HDL subclasses remained unchanged. The fractional catabolic rate (FCR) of [
131
I]-apo A-I in the proteinuric rabbits was faster (FCR = 0.036 h
−1
) compared to control rabbits group (FCR = 0.026 h
−1
,
P
< 0.05). Apo E increased and apo A-I decreased in HDL, whereas PON-1 activity increased in proteinuric rabbits. Proteinuria was associated with an increased number of large HDL2b particles and a decreased number of small HDL3b and 3c. Proteinuria was also connected to an alteration in HDL subclass lipids, apolipoprotein content of HDL, high paraoxonase-1 activity, and a rise in the fractional catabolic rate of the [
131
I]-apo A-I.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-016-4120-6</identifier><identifier>PMID: 26781765</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Administration, Intravenous ; Animals ; Apolipoprotein A-I - chemistry ; Apolipoprotein A-I - metabolism ; Atherosclerosis ; Biomedical and Life Sciences ; Coronary heart disease ; Doxorubicin - administration & dosage ; Doxorubicin - adverse effects ; HDL ; Intravenous administration ; Iodine radioisotopes ; Life Sciences ; Lipidology ; Lipids ; Lipoprotein metabolism ; Lipoproteins, HDL - chemistry ; Lipoproteins, HDL - metabolism ; Male ; Medical Biochemistry ; Medicinal Chemistry ; Microbial Genetics and Genomics ; Neurochemistry ; Nutrition ; Original Article ; Paraoxonase‐1 ; Particle Size ; Proteinuria - chemically induced ; Proteinuria - metabolism ; Rabbits ; Renal failure</subject><ispartof>Lipids, 2016-03, Vol.51 (3), p.311-320</ispartof><rights>AOCS 2016</rights><rights>2016 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373</citedby><cites>FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-016-4120-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-016-4120-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1644,27924,27925,41418,42487,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26781765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Olmos, Victoria</creatorcontrib><creatorcontrib>Carreón-Torres, Elizabeth</creatorcontrib><creatorcontrib>Luna-Luna, María</creatorcontrib><creatorcontrib>Flores-Castillo, Cristobal</creatorcontrib><creatorcontrib>Martínez-Ramírez, Miriam</creatorcontrib><creatorcontrib>Bautista-Pérez, Rocío</creatorcontrib><creatorcontrib>Franco, Martha</creatorcontrib><creatorcontrib>Sandoval-Zárate, Julio</creatorcontrib><creatorcontrib>Roldán, Francisco-Javier</creatorcontrib><creatorcontrib>Aranda-Fraustro, Alberto</creatorcontrib><creatorcontrib>Soria-Castro, Elizabeth</creatorcontrib><creatorcontrib>Muñoz-Vega, Mónica</creatorcontrib><creatorcontrib>Fragoso, José-Manuel</creatorcontrib><creatorcontrib>Vargas-Alarcón, Gilberto</creatorcontrib><creatorcontrib>Pérez-Méndez, Oscar</creatorcontrib><title>Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties. To better understand the role of the kidney in HDL catabolism, here we characterized HDL subclasses and the catabolic rates of apo A-I in a rabbit model of proteinuria. Proteinuria was induced by intravenous administration of doxorubicin in New Zealand white rabbits (
n
= 10). HDL size and HDL subclass lipids were assessed by electrophoresis of the isolated lipoproteins. The catabolic rate of HDL-apo A-I was evaluated by exogenous radiolabelling with iodine-131. Doxorubicin induced significant proteinuria after 4 weeks (4.47 ± 0.55 vs. 0.30 ± 0.02 g/L of protein in urine,
P
< 0.001) associated with increased uremia, creatininemia, and cardiotoxicity. Large HDL2b augmented significantly during proteinuria, whereas small HDL3b and HDL3c decreased compared to basal conditions. HDL2b, HDL2a, and HDL3a subclasses were enriched with triacylglycerols in proteinuric animals as determined by the triacylglycerol-to-phospholipid ratio; the cholesterol content in HDL subclasses remained unchanged. The fractional catabolic rate (FCR) of [
131
I]-apo A-I in the proteinuric rabbits was faster (FCR = 0.036 h
−1
) compared to control rabbits group (FCR = 0.026 h
−1
,
P
< 0.05). Apo E increased and apo A-I decreased in HDL, whereas PON-1 activity increased in proteinuric rabbits. Proteinuria was associated with an increased number of large HDL2b particles and a decreased number of small HDL3b and 3c. Proteinuria was also connected to an alteration in HDL subclass lipids, apolipoprotein content of HDL, high paraoxonase-1 activity, and a rise in the fractional catabolic rate of the [
131
I]-apo A-I.</description><subject>Administration, Intravenous</subject><subject>Animals</subject><subject>Apolipoprotein A-I - chemistry</subject><subject>Apolipoprotein A-I - metabolism</subject><subject>Atherosclerosis</subject><subject>Biomedical and Life Sciences</subject><subject>Coronary heart disease</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - adverse effects</subject><subject>HDL</subject><subject>Intravenous administration</subject><subject>Iodine radioisotopes</subject><subject>Life Sciences</subject><subject>Lipidology</subject><subject>Lipids</subject><subject>Lipoprotein metabolism</subject><subject>Lipoproteins, HDL - chemistry</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Microbial Genetics and Genomics</subject><subject>Neurochemistry</subject><subject>Nutrition</subject><subject>Original Article</subject><subject>Paraoxonase‐1</subject><subject>Particle Size</subject><subject>Proteinuria - chemically induced</subject><subject>Proteinuria - metabolism</subject><subject>Rabbits</subject><subject>Renal failure</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkF1rFDEUhoModlv9Ad5IwOvUnJnMZHO57FY7sGjxg4I3IR9n3JRtZk1mqPUX-LPNMlW8Ea_CCe_znMNLyAvg58C5fJ0BpGgYh5YJqDhrH5EFNM2SqZrLx2TBeSWYqDickNOcb8oIQjVPyUnVyiXItlmQn110CU1GTy83W_ox_EBqoqcXcWeiK7-rw0BXrKNrMxo77IOjH8yIma4S0lXOgwtl9PQ6jDu6Gb4PabLBhci66Kcjf5WGEUOcUjA0RPoO7-gXNPvjjutdGLHorA1jfkae9Gaf8fnDe0Y-v7n4tL5k2_dvu_Vqy5xQHBhKJ0BKAarirvWt6iXH3qKV3ioB6G2j-mWlWtP3ftkIcF61XElneqlsLesz8mr2HtLwbcI86pthSrGs1MULgteiqkoK5pRLQ84Je31I4dakew1cH7vXc_e6dK-P3eu2MC8fzJO9Rf-H-F12Ccg5cBf2eP9_o952VxteAxSymslcoPgV019H__OeXzVNnrk</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>López-Olmos, 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HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits</title><author>López-Olmos, Victoria ; Carreón-Torres, Elizabeth ; Luna-Luna, María ; Flores-Castillo, Cristobal ; Martínez-Ramírez, Miriam ; Bautista-Pérez, Rocío ; Franco, Martha ; Sandoval-Zárate, Julio ; Roldán, Francisco-Javier ; Aranda-Fraustro, Alberto ; Soria-Castro, Elizabeth ; Muñoz-Vega, Mónica ; Fragoso, José-Manuel ; Vargas-Alarcón, Gilberto ; Pérez-Méndez, Oscar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Intravenous</topic><topic>Animals</topic><topic>Apolipoprotein A-I - chemistry</topic><topic>Apolipoprotein A-I - metabolism</topic><topic>Atherosclerosis</topic><topic>Biomedical and Life Sciences</topic><topic>Coronary heart disease</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - adverse effects</topic><topic>HDL</topic><topic>Intravenous administration</topic><topic>Iodine radioisotopes</topic><topic>Life Sciences</topic><topic>Lipidology</topic><topic>Lipids</topic><topic>Lipoprotein metabolism</topic><topic>Lipoproteins, HDL - chemistry</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Medicinal Chemistry</topic><topic>Microbial Genetics and Genomics</topic><topic>Neurochemistry</topic><topic>Nutrition</topic><topic>Original Article</topic><topic>Paraoxonase‐1</topic><topic>Particle Size</topic><topic>Proteinuria - chemically induced</topic><topic>Proteinuria - metabolism</topic><topic>Rabbits</topic><topic>Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Olmos, 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Olmos, Victoria</au><au>Carreón-Torres, Elizabeth</au><au>Luna-Luna, María</au><au>Flores-Castillo, Cristobal</au><au>Martínez-Ramírez, Miriam</au><au>Bautista-Pérez, Rocío</au><au>Franco, Martha</au><au>Sandoval-Zárate, Julio</au><au>Roldán, Francisco-Javier</au><au>Aranda-Fraustro, Alberto</au><au>Soria-Castro, Elizabeth</au><au>Muñoz-Vega, Mónica</au><au>Fragoso, José-Manuel</au><au>Vargas-Alarcón, Gilberto</au><au>Pérez-Méndez, Oscar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits</atitle><jtitle>Lipids</jtitle><stitle>Lipids</stitle><addtitle>Lipids</addtitle><date>2016-03</date><risdate>2016</risdate><volume>51</volume><issue>3</issue><spage>311</spage><epage>320</epage><pages>311-320</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties. To better understand the role of the kidney in HDL catabolism, here we characterized HDL subclasses and the catabolic rates of apo A-I in a rabbit model of proteinuria. Proteinuria was induced by intravenous administration of doxorubicin in New Zealand white rabbits (
n
= 10). HDL size and HDL subclass lipids were assessed by electrophoresis of the isolated lipoproteins. The catabolic rate of HDL-apo A-I was evaluated by exogenous radiolabelling with iodine-131. Doxorubicin induced significant proteinuria after 4 weeks (4.47 ± 0.55 vs. 0.30 ± 0.02 g/L of protein in urine,
P
< 0.001) associated with increased uremia, creatininemia, and cardiotoxicity. Large HDL2b augmented significantly during proteinuria, whereas small HDL3b and HDL3c decreased compared to basal conditions. HDL2b, HDL2a, and HDL3a subclasses were enriched with triacylglycerols in proteinuric animals as determined by the triacylglycerol-to-phospholipid ratio; the cholesterol content in HDL subclasses remained unchanged. The fractional catabolic rate (FCR) of [
131
I]-apo A-I in the proteinuric rabbits was faster (FCR = 0.036 h
−1
) compared to control rabbits group (FCR = 0.026 h
−1
,
P
< 0.05). Apo E increased and apo A-I decreased in HDL, whereas PON-1 activity increased in proteinuric rabbits. Proteinuria was associated with an increased number of large HDL2b particles and a decreased number of small HDL3b and 3c. Proteinuria was also connected to an alteration in HDL subclass lipids, apolipoprotein content of HDL, high paraoxonase-1 activity, and a rise in the fractional catabolic rate of the [
131
I]-apo A-I.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26781765</pmid><doi>10.1007/s11745-016-4120-6</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-4201 |
| ispartof | Lipids, 2016-03, Vol.51 (3), p.311-320 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_proquest_journals_1771403422 |
| source | Wiley; Springer Journals |
| subjects | Administration, Intravenous Animals Apolipoprotein A-I - chemistry Apolipoprotein A-I - metabolism Atherosclerosis Biomedical and Life Sciences Coronary heart disease Doxorubicin - administration & dosage Doxorubicin - adverse effects HDL Intravenous administration Iodine radioisotopes Life Sciences Lipidology Lipids Lipoprotein metabolism Lipoproteins, HDL - chemistry Lipoproteins, HDL - metabolism Male Medical Biochemistry Medicinal Chemistry Microbial Genetics and Genomics Neurochemistry Nutrition Original Article Paraoxonase‐1 Particle Size Proteinuria - chemically induced Proteinuria - metabolism Rabbits Renal failure |
| title | Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T08%3A22%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20HDL%20Size%20and%20Enhanced%20Apo%20A-I%20Catabolic%20Rates%20Are%20Associated%20With%20Doxorubicin-Induced%20Proteinuria%20in%20New%20Zealand%20White%20Rabbits&rft.jtitle=Lipids&rft.au=L%C3%B3pez-Olmos,%20Victoria&rft.date=2016-03&rft.volume=51&rft.issue=3&rft.spage=311&rft.epage=320&rft.pages=311-320&rft.issn=0024-4201&rft.eissn=1558-9307&rft_id=info:doi/10.1007/s11745-016-4120-6&rft_dat=%3Cproquest_cross%3E3974638251%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4901-e7c417741920c6d69f70efbeb7db941edb59f8296affd8541cd96097caf79b373%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1771403422&rft_id=info:pmid/26781765&rfr_iscdi=true |