Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine

We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo...

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Published in:Bulletin of experimental biology and medicine 2015-01, Vol.158 (3), p.326
Main Authors: Yurkiv, V A, Melikhov, V I, Shubin, V S
Format: Article
Language:English
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Summary:We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca^sup 2+^ on Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase. A possible mechanism of regulation of enzyme activity by Ca^sup 2+^ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl^sup -^ ions was proposed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2753-8