Loading…
Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine
We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo...
Saved in:
| Published in: | Bulletin of experimental biology and medicine 2015-01, Vol.158 (3), p.326 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | 3 |
| container_start_page | 326 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 158 |
| creator | Yurkiv, V A Melikhov, V I Shubin, V S |
| description | We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca^sup 2+^ on Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase. A possible mechanism of regulation of enzyme activity by Ca^sup 2+^ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl^sup -^ ions was proposed. |
| doi_str_mv | 10.1007/s10517-015-2753-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1773246410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3984867211</sourcerecordid><originalsourceid>FETCH-proquest_journals_17732464103</originalsourceid><addsrcrecordid>eNqNi81OAjEUhRsjiaP4AO5u4kaD1d7ODJ0tmWBg4U-AdUmHFC2pLdKWRJ_eojyAq_udc75LyBWye2RMPARkNQrKsKZc1CVtTkiBtcjAOZ6SgmWJVk3TnJHzEDaHyIZYkO9WyZC2wAcSpt4FmOm3ZFXUMFpFszfxC_wanv-kgbxr7S9ReTNpXzJ2UMpjc0tHi1cVNBgH8V3DU1r5oA7vM9V1JsL8Q1kLUxd1iMbpPumtlQ368ngvyPXjeNFO6HbnP1N2lhufdi5PSxSi5NWwQlb-z_oBaZpRMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1773246410</pqid></control><display><type>article</type><title>Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine</title><source>Springer Nature</source><creator>Yurkiv, V A ; Melikhov, V I ; Shubin, V S</creator><creatorcontrib>Yurkiv, V A ; Melikhov, V I ; Shubin, V S</creatorcontrib><description>We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca^sup 2+^ on Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase. A possible mechanism of regulation of enzyme activity by Ca^sup 2+^ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl^sup -^ ions was proposed.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-015-2753-8</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>New York: Springer Nature B.V</publisher><ispartof>Bulletin of experimental biology and medicine, 2015-01, Vol.158 (3), p.326</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Yurkiv, V A</creatorcontrib><creatorcontrib>Melikhov, V I</creatorcontrib><creatorcontrib>Shubin, V S</creatorcontrib><title>Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine</title><title>Bulletin of experimental biology and medicine</title><description>We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca^sup 2+^ on Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase. A possible mechanism of regulation of enzyme activity by Ca^sup 2+^ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl^sup -^ ions was proposed.</description><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNi81OAjEUhRsjiaP4AO5u4kaD1d7ODJ0tmWBg4U-AdUmHFC2pLdKWRJ_eojyAq_udc75LyBWye2RMPARkNQrKsKZc1CVtTkiBtcjAOZ6SgmWJVk3TnJHzEDaHyIZYkO9WyZC2wAcSpt4FmOm3ZFXUMFpFszfxC_wanv-kgbxr7S9ReTNpXzJ2UMpjc0tHi1cVNBgH8V3DU1r5oA7vM9V1JsL8Q1kLUxd1iMbpPumtlQ368ngvyPXjeNFO6HbnP1N2lhufdi5PSxSi5NWwQlb-z_oBaZpRMQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Yurkiv, V A</creator><creator>Melikhov, V I</creator><creator>Shubin, V S</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150101</creationdate><title>Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine</title><author>Yurkiv, V A ; Melikhov, V I ; Shubin, V S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_17732464103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yurkiv, V A</creatorcontrib><creatorcontrib>Melikhov, V I</creatorcontrib><creatorcontrib>Shubin, V S</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yurkiv, V A</au><au>Melikhov, V I</au><au>Shubin, V S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><date>2015-01-01</date><risdate>2015</risdate><volume>158</volume><issue>3</issue><spage>326</spage><pages>326-</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>We studied the effects of bivalent metal ions on activity of Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase was studied. In contrast to Ba^sup 2+^, Co^sup 2+^, Zn^sup 2+^, and Mn^sup 2+^ ions, Ca^sup 2+^ and Mg^sup 2+^ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca^sup 2+^ on Na^sup +^,Cl^sup -^(HCO3 ^sup -^)-ATPase. A possible mechanism of regulation of enzyme activity by Ca^sup 2+^ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl^sup -^ ions was proposed.</abstract><cop>New York</cop><pub>Springer Nature B.V</pub><doi>10.1007/s10517-015-2753-8</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2015-01, Vol.158 (3), p.326 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_journals_1773246410 |
| source | Springer Nature |
| title | Ca^sup 2+^ Ions Regulate Activity of Na^sup +^,Cl^sup -^(HCO^sub 3^^sup -^)-ATPase in the Mucosa of Rabbit Small Intestine |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T13%3A31%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ca%5Esup%202+%5E%20Ions%20Regulate%20Activity%20of%20Na%5Esup%20+%5E,Cl%5Esup%20-%5E(HCO%5Esub%203%5E%5Esup%20-%5E)-ATPase%20in%20the%20Mucosa%20of%20Rabbit%20Small%20Intestine&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Yurkiv,%20V%20A&rft.date=2015-01-01&rft.volume=158&rft.issue=3&rft.spage=326&rft.pages=326-&rft.issn=0007-4888&rft.eissn=1573-8221&rft.coden=BEXBAN&rft_id=info:doi/10.1007/s10517-015-2753-8&rft_dat=%3Cproquest%3E3984867211%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_17732464103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1773246410&rft_id=info:pmid/&rfr_iscdi=true |