Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

• Published in: Archives of Dermatological Research 2016-04, Vol.308 (3), p.165-171
• Main Authors: Lopes, Maria Luiza Diniz de Sousa, de Oliveira, Denise Hélen Imaculada Pereira, Sarmento, Dmitry José de Santana, Queiroz, Lélia Maria Guedes, Miguel, Márcia Cristina da Costa, da Silveira, Éricka Janine Dantas
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Carcinogenesis - metabolism; Carcinogenesis - pathology; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Cycle Proteins - metabolism; Cheilitis - metabolism; Cheilitis - pathology; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Dermatology; Female; Humans; Immunohistochemistry; Lip - pathology; Lip Neoplasms - metabolism; Lip Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; MutS Homolog 2 Protein - metabolism; Neoplasm Grading; Original Paper; Retrospective Studies; Tumor Suppressor Protein p53 - metabolism
• ISSN: 0340-3696; 1432-069X
• DOI: 10.1007/s00403-016-1625-z

This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC ( p  > 0.05). Immunoexpression of p53 was higher in SCC than in AC ( p