Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice

FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of...

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Bibliographic Details
Published in:Biogerontology (Dordrecht) 2016-04, Vol.17 (2), p.317-324
Main Authors: Panchenko, Andrey V., Popovich, Irina G., Trashkov, Alexandr P., Egormin, Peter A., Yurova, Maria N., Tyndyk, Margarita L., Gubareva, Ekaterina A., Artyukin, Ilia N., Vasiliev, Andrey G., Khaitsev, Nikolai V., Zabezhinski, Mark A., Anisimov, Vladimir N.
Format: Article
Language:English
Subjects:
Age
Aging
Animals
Biomarkers
Biomarkers - metabolism
Biomedical and Life Sciences
Cancer
Carcinogenesis
Cell Biology
Developmental Biology
Embryos
Female
Genes, erbB-2
Geriatrics/Gerontology
Insulin-like growth factors
Life Sciences
Metabolism
Mice
Mice, Transgenic
Oncology
Research Article
Research centers
Tumors
Vascular endothelial growth factor
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Summary:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis.
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-015-9611-y