Drug points: Erythromycin deafness and cimetidine treatment

Audiography showed bilateral hearing loss of 40-60 dB at frequencies of 0.25-8 kHz; hearing returned to normal five days after erythromycin was withdrawn. Since cimetidine inhibits the N-demethylation of erythromycin in vitro, 1 we investigated a possible interaction in six healthy men and two women...

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Bibliographic Details
Published in:BMJ 1994-12, Vol.309 (6969), p.1620-1620
Main Authors: Mogford, N, Pallett, A, George, C
Format: Article
Language:English
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Summary:Audiography showed bilateral hearing loss of 40-60 dB at frequencies of 0.25-8 kHz; hearing returned to normal five days after erythromycin was withdrawn. Since cimetidine inhibits the N-demethylation of erythromycin in vitro, 1 we investigated a possible interaction in six healthy men and two women aged 19-23.
ISSN:0959-8138
1468-5833
DOI:10.1136/bmj.309.6969.1620c