Embryonic abnormalities at medical termination of pregnancy

Three investigators studied each embryo independently before a classification was determined; when a neural tube defect was suspected on macroscopic inspection, the periderm (future dermis) was examined meticulously and the embryo was classed as having a neural tube defect only if the skin surface w...

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Bibliographic Details
Published in:BMJ 1998-11, Vol.317 (7170), p.1452-1453
Main Authors: Jarmulowicz, Michael, Quenby, Siobhan, Blanch, Geraldine, Neilson, James
Format: Article
Language:English
Subjects:
Abdomen
Embryological stage
Embryos
Gestational sac
Histology
Letters
Neural tube defects
Pregnancy
Pregnancy rate
Premature birth
Ultrasonography
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Summary:Three investigators studied each embryo independently before a classification was determined; when a neural tube defect was suspected on macroscopic inspection, the periderm (future dermis) was examined meticulously and the embryo was classed as having a neural tube defect only if the skin surface was continuous with the developing neural tissue; abdominal wall defects were diagnosed only if there were loops of bowel outside the abdominal wall before Carnegie stage 16 or if other intra-abdominal organs such as the liver were outside the abdominal wall and if the edge of the periderm was histologically rounded rather than ragged.
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.317.7170.1452