Molecular stool screening for colorectal cancer

DNA is an intriguing alternative marker in the stool for reasons that are, theoretically, compelling. Firstly, DNA is released into the faecal stream continuously via exfoliation rather than intermittently via bleeding, which could enhance sensitivity and obviate the need for multiple stool tests du...

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Bibliographic Details
Published in:BMJ 2000-07, Vol.321 (7256), p.254-255
Main Author: Ahlquist, David A
Format: Article
Language:English
Subjects:
Colorectal cancer
Deoxyribonucleic acid
DNA
Medical screening
Molecules
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Summary:DNA is an intriguing alternative marker in the stool for reasons that are, theoretically, compelling. Firstly, DNA is released into the faecal stream continuously via exfoliation rather than intermittently via bleeding, which could enhance sensitivity and obviate the need for multiple stool tests during each screening. Secondly, DNA comes from the neoplasm itself rather than from the circulation, which could improve specificity.
ISSN:0959-8138
0959-8146
1468-5833
DOI:10.1136/bmj.321.7256.254