Co-proxamol and suicide

EDITOR-We agree with Hawton et al that co-proxamol presents a major overdose hazard, their results illustrating the difficulties for licensing authorities in limiting availability of prescription medicines that are only hazardous in overdose. 1 Co-proxamol is more likely to result in death; it cause...

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Bibliographic Details
Published in:BMJ 2003-07, Vol.327 (7409), p.287-287
Main Authors: Bateman, D N, Afshari, R
Format: Article
Language:English
Subjects:
Letters
Mortality
Narcotics
Opioid analgesics
Pain
Pharmaceutical industry
Poisoning
Prescription drugs
Public health
Suicide
Toxicity
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Summary:EDITOR-We agree with Hawton et al that co-proxamol presents a major overdose hazard, their results illustrating the difficulties for licensing authorities in limiting availability of prescription medicines that are only hazardous in overdose. 1 Co-proxamol is more likely to result in death; it causes prolongation of the QRS interval in an electrocardiogram in experimental animals and in humans. 2 3 This property is usually associated with sodium channel blockade and is a precursor to ventricular arrhythmia.
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.327.7409.287