OP10 Effects of socio Economic Position in Childhood and Adulthood on Cardiometabolic Risk Factors: The Jerusalem Perinatal Family Follow-Up Study

• Published in: Journal of epidemiology and community health (1979) 2012-09, Vol.66 (Suppl 1), p.A4-A5
• Main Authors: Manor, O, Savitsky, B, Hochner, H, Meiner, V, Siscovick, DS, Friedlander, Y
• Format: Article
• Language: English
• Subjects: Blood pressure; Economics; Education; Health risks; Insulin; Risk factors; Risk taking; Young adults
• ISSN: 0143-005X; 1470-2738
• DOI: 10.1136/jech-2012-201753.010

Background Studies indicate that Socio Economic Position (SEP) might be an important predictor of cardiometabolic disease mortality and morbidity; yet the importance of timing of the effect of SEP on cardiometabolic risk factors has not been fully established. Our aim was to assess the independent effect of SEP in both childhood and adulthood on cardiometabolic risk factors in young adults and to examine potential interactive effects of SEP at both time points on these risk factors. Methods This is a prospective follow-up of 1132 individuals, born in Jerusalem between the years 1974–76, to young adulthood with bio-medical data at mean age 32. Outcomes include Body Mass Index (BMI), Waist to Hip Ratio (WHR), blood pressure, waist circumference (WC), pelvis circumference, body fat percentage, fasting levels of Triglyceride (TG), HDL-C, LDL-C, glucose, insulin, and lifestyle characteristics, including smoking and physical activity. SEP in childhood was based on father’s occupation (scale 1–6) and in adulthood, on subject’s occupation (scale 1–5). Additional analyses used maternal and subject’s years of education. GLM and logistic regression models were used with mutual adjustment for SEP at both time points and further adjustment for gender, ethnic origin and fasting duration. Log transformation was used for TG and insulin levels. Results Independently of current SEP, lower childhood SEP was significantly associated with higher logTG (β=0.013, p=0.042), higher LDL (β=1.979, p=0.023), higher body fat percentage (β=0.476, p=0.025) and higher odds of physical inactivity (OR=1.13, p=0.043). Independently of childhood SEP, lower adulthood SEP was significantly associated with lower HDL level (β=–0.934, p=0.026), higher WHR (β=0.006, p=0.002), and higher odds of smoking (OR=1.31, p=0.001) and physical inactivity (OR=1.34, p