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Genetic polymorphisms, concussion risk, and post concussion neurocognitive deficits in college and high school athletes
Objective To investigate associations of APOE and Tau gene polymorphisms with sports-related acute concussions and baseline to post-concussion neuropsychological test score changes. Design Multi-center prospective cohort study. Setting Scholarship athletes at 21 universities and 4 high schools Parti...
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Published in: | British journal of sports medicine 2013-04, Vol.47 (5), p.e1-e1 |
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description | Objective To investigate associations of APOE and Tau gene polymorphisms with sports-related acute concussions and baseline to post-concussion neuropsychological test score changes. Design Multi-center prospective cohort study. Setting Scholarship athletes at 21 universities and 4 high schools Participants: 3218 athletes playing football (70%) or soccer (23%). Assessment of Risk Factors APOE, APOE G-219T promoter (APOEProm), Tau exon 6 Ser53Pro (TauSer), and Tau exon 6 Hist47Tyr (TauHis) genetic polymorphisms. Main Outcome Measurements (1) Acute concussions and (2) differences between baseline and 24–72 h post-concussion Headminder Neuropsychological Test Scores of Simple and Complex Reaction Time (SRT and CRT, respectively) and Processing Speed. Results There were a total of 131 athletes with incident concussions and genetic data and neuropsychological test scores. There were no statistically significant differences in frequencies of acute concussions according to genotypes by χ2 test. By t-test, the mean baseline to post-concussion neuropsychological changes were statistically significantly greater for CRT and SRT in those with the TauSer ‘TT’ genotype and for CRT in those with the APOEProm ‘TT’ genotype, and borderline significantly greater in those with the TauSer ‘TT’ genotype (p=0.09). Conclusions The statistically significantly worse mean baseline to post-concussion neuropsychological test scores in those with the APOEProm and TauSer polymorphisms suggests a possible genetic influence on post-concussion neurocognitive recovery. These preliminary findings provide no evidence for associations of the four APOE and Tau gene polymorphisms investigated with acute concussions, although the small sample size and lack of control for confounders are limitations. Acknowledgements Grant funding was provided through the NOCSAE (National Operating Committee for Safety Athletic Equipment) and the American Medical Society for Sports Medicine (AMSSM) Foundations. The opinions expressed in this abstract are not those of NOCSAE or AMSSM. Competing interests None. |
doi_str_mv | 10.1136/bjsports-2012-092101.31 |
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Design Multi-center prospective cohort study. Setting Scholarship athletes at 21 universities and 4 high schools Participants: 3218 athletes playing football (70%) or soccer (23%). Assessment of Risk Factors APOE, APOE G-219T promoter (APOEProm), Tau exon 6 Ser53Pro (TauSer), and Tau exon 6 Hist47Tyr (TauHis) genetic polymorphisms. Main Outcome Measurements (1) Acute concussions and (2) differences between baseline and 24–72 h post-concussion Headminder Neuropsychological Test Scores of Simple and Complex Reaction Time (SRT and CRT, respectively) and Processing Speed. Results There were a total of 131 athletes with incident concussions and genetic data and neuropsychological test scores. There were no statistically significant differences in frequencies of acute concussions according to genotypes by χ2 test. By t-test, the mean baseline to post-concussion neuropsychological changes were statistically significantly greater for CRT and SRT in those with the TauSer ‘TT’ genotype and for CRT in those with the APOEProm ‘TT’ genotype, and borderline significantly greater in those with the TauSer ‘TT’ genotype (p=0.09). Conclusions The statistically significantly worse mean baseline to post-concussion neuropsychological test scores in those with the APOEProm and TauSer polymorphisms suggests a possible genetic influence on post-concussion neurocognitive recovery. These preliminary findings provide no evidence for associations of the four APOE and Tau gene polymorphisms investigated with acute concussions, although the small sample size and lack of control for confounders are limitations. Acknowledgements Grant funding was provided through the NOCSAE (National Operating Committee for Safety Athletic Equipment) and the American Medical Society for Sports Medicine (AMSSM) Foundations. The opinions expressed in this abstract are not those of NOCSAE or AMSSM. Competing interests None.</description><identifier>ISSN: 0306-3674</identifier><identifier>EISSN: 1473-0480</identifier><identifier>DOI: 10.1136/bjsports-2012-092101.31</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine</publisher><ispartof>British journal of sports medicine, 2013-04, Vol.47 (5), p.e1-e1</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b2112-6a9322539a36a78f3f607f03825a7346487a264e4ce334a234d52a9cabb09b793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjsm.bmj.com/content/47/5/e1.25.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjsm.bmj.com/content/47/5/e1.25.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>112,113,314,780,784,3194,27924,27925,77594,77595</link.rule.ids></links><search><creatorcontrib>Terrell, Thomas R</creatorcontrib><creatorcontrib>Bostick, Roberd M</creatorcontrib><creatorcontrib>Barth, Jeffery</creatorcontrib><creatorcontrib>McKeag, Douglas</creatorcontrib><creatorcontrib>Cantu, Robert C</creatorcontrib><creatorcontrib>Sloane, Rick</creatorcontrib><creatorcontrib>Galloway, Leslie</creatorcontrib><creatorcontrib>Erlanger, David</creatorcontrib><creatorcontrib>Valentine, Verle</creatorcontrib><creatorcontrib>Bielak, K</creatorcontrib><title>Genetic polymorphisms, concussion risk, and post concussion neurocognitive deficits in college and high school athletes</title><title>British journal of sports medicine</title><addtitle>Br J Sports Med</addtitle><description>Objective To investigate associations of APOE and Tau gene polymorphisms with sports-related acute concussions and baseline to post-concussion neuropsychological test score changes. Design Multi-center prospective cohort study. Setting Scholarship athletes at 21 universities and 4 high schools Participants: 3218 athletes playing football (70%) or soccer (23%). Assessment of Risk Factors APOE, APOE G-219T promoter (APOEProm), Tau exon 6 Ser53Pro (TauSer), and Tau exon 6 Hist47Tyr (TauHis) genetic polymorphisms. Main Outcome Measurements (1) Acute concussions and (2) differences between baseline and 24–72 h post-concussion Headminder Neuropsychological Test Scores of Simple and Complex Reaction Time (SRT and CRT, respectively) and Processing Speed. Results There were a total of 131 athletes with incident concussions and genetic data and neuropsychological test scores. There were no statistically significant differences in frequencies of acute concussions according to genotypes by χ2 test. By t-test, the mean baseline to post-concussion neuropsychological changes were statistically significantly greater for CRT and SRT in those with the TauSer ‘TT’ genotype and for CRT in those with the APOEProm ‘TT’ genotype, and borderline significantly greater in those with the TauSer ‘TT’ genotype (p=0.09). Conclusions The statistically significantly worse mean baseline to post-concussion neuropsychological test scores in those with the APOEProm and TauSer polymorphisms suggests a possible genetic influence on post-concussion neurocognitive recovery. These preliminary findings provide no evidence for associations of the four APOE and Tau gene polymorphisms investigated with acute concussions, although the small sample size and lack of control for confounders are limitations. Acknowledgements Grant funding was provided through the NOCSAE (National Operating Committee for Safety Athletic Equipment) and the American Medical Society for Sports Medicine (AMSSM) Foundations. The opinions expressed in this abstract are not those of NOCSAE or AMSSM. Competing interests None.</description><issn>0306-3674</issn><issn>1473-0480</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkMFO3DAQhq2qSN1Cn6GReiVgexw7OVYLBaQVFRLt1XK8zsZLNk493gJvjyEFcexpDv_3zWh-Qr4yesIYyNN2i1OICUtOGS9pwxllJ8A-kAUTCkoqavqRLChQWYJU4hP5jLilma1ovSD3F250ydtiCsPjLsSp97jD48KG0e4RfRiL6PHuuDDjOjOY3iej28dgw2b0yf91xdp13vqEhR8zNQxu41603m_6Am0fwlCY1A8uOTwiB50Z0H35Nw_Jrx_nt8vLcvXz4mr5fVW2nOV3pGmA8woaA9KouoNOUtVRqHllFAgpamW4FE5YByAMB7GuuGmsaVvatKqBQ_Jt3jvF8GfvMOlt2Mcxn9RM5bwSVPBMqZmyMSBG1-kp-p2Jj5pR_dyyfm1ZP7es55Y1sGyWs-kxuYc3zcQ7LRWoSl__Xmq4YRJuqpU-yzyf-Xa3_e8jTxg4kx4</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Terrell, Thomas R</creator><creator>Bostick, Roberd M</creator><creator>Barth, Jeffery</creator><creator>McKeag, Douglas</creator><creator>Cantu, Robert C</creator><creator>Sloane, Rick</creator><creator>Galloway, Leslie</creator><creator>Erlanger, David</creator><creator>Valentine, Verle</creator><creator>Bielak, K</creator><general>BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201304</creationdate><title>Genetic polymorphisms, concussion risk, and post concussion neurocognitive deficits in college and high school athletes</title><author>Terrell, Thomas R ; Bostick, Roberd M ; Barth, Jeffery ; McKeag, Douglas ; Cantu, Robert C ; Sloane, Rick ; Galloway, Leslie ; Erlanger, David ; Valentine, Verle ; Bielak, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2112-6a9322539a36a78f3f607f03825a7346487a264e4ce334a234d52a9cabb09b793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terrell, Thomas R</creatorcontrib><creatorcontrib>Bostick, Roberd M</creatorcontrib><creatorcontrib>Barth, Jeffery</creatorcontrib><creatorcontrib>McKeag, Douglas</creatorcontrib><creatorcontrib>Cantu, Robert C</creatorcontrib><creatorcontrib>Sloane, Rick</creatorcontrib><creatorcontrib>Galloway, Leslie</creatorcontrib><creatorcontrib>Erlanger, David</creatorcontrib><creatorcontrib>Valentine, Verle</creatorcontrib><creatorcontrib>Bielak, K</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>ProQuest Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>British journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terrell, Thomas R</au><au>Bostick, Roberd M</au><au>Barth, Jeffery</au><au>McKeag, Douglas</au><au>Cantu, Robert C</au><au>Sloane, Rick</au><au>Galloway, Leslie</au><au>Erlanger, David</au><au>Valentine, Verle</au><au>Bielak, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphisms, concussion risk, and post concussion neurocognitive deficits in college and high school athletes</atitle><jtitle>British journal of sports medicine</jtitle><addtitle>Br J Sports Med</addtitle><date>2013-04</date><risdate>2013</risdate><volume>47</volume><issue>5</issue><spage>e1</spage><epage>e1</epage><pages>e1-e1</pages><issn>0306-3674</issn><eissn>1473-0480</eissn><abstract>Objective To investigate associations of APOE and Tau gene polymorphisms with sports-related acute concussions and baseline to post-concussion neuropsychological test score changes. Design Multi-center prospective cohort study. Setting Scholarship athletes at 21 universities and 4 high schools Participants: 3218 athletes playing football (70%) or soccer (23%). Assessment of Risk Factors APOE, APOE G-219T promoter (APOEProm), Tau exon 6 Ser53Pro (TauSer), and Tau exon 6 Hist47Tyr (TauHis) genetic polymorphisms. Main Outcome Measurements (1) Acute concussions and (2) differences between baseline and 24–72 h post-concussion Headminder Neuropsychological Test Scores of Simple and Complex Reaction Time (SRT and CRT, respectively) and Processing Speed. Results There were a total of 131 athletes with incident concussions and genetic data and neuropsychological test scores. There were no statistically significant differences in frequencies of acute concussions according to genotypes by χ2 test. By t-test, the mean baseline to post-concussion neuropsychological changes were statistically significantly greater for CRT and SRT in those with the TauSer ‘TT’ genotype and for CRT in those with the APOEProm ‘TT’ genotype, and borderline significantly greater in those with the TauSer ‘TT’ genotype (p=0.09). Conclusions The statistically significantly worse mean baseline to post-concussion neuropsychological test scores in those with the APOEProm and TauSer polymorphisms suggests a possible genetic influence on post-concussion neurocognitive recovery. These preliminary findings provide no evidence for associations of the four APOE and Tau gene polymorphisms investigated with acute concussions, although the small sample size and lack of control for confounders are limitations. Acknowledgements Grant funding was provided through the NOCSAE (National Operating Committee for Safety Athletic Equipment) and the American Medical Society for Sports Medicine (AMSSM) Foundations. The opinions expressed in this abstract are not those of NOCSAE or AMSSM. Competing interests None.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine</pub><doi>10.1136/bjsports-2012-092101.31</doi></addata></record> |
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title | Genetic polymorphisms, concussion risk, and post concussion neurocognitive deficits in college and high school athletes |
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