THE CARDIAC BIOMARKERS IN CHILDREN WITH CARDIOMYOPATHY MULTICENTER STUDY: PRELIMINARY RESULTS FOR PEDIATRIC HYPERTROPHIC CARDIOMYOPATHY

• Published in: Journal of the American College of Cardiology 2016-04, Vol.67 (13), p.1509-1509
• Main Authors: Lipshultz, Steven, Wilkinson, James, Shi, Ling, Towbin, Jeffrey, Canter, Charles, Hsu, Daphne, Webber, Steven, Kantor, Paul, Everitt, Melanie, Pahl, Elfriede, Jefferies, John, Rossano, Joseph, Addonizio, Linda, Dodd, Debra, Ware, Stephanie, Molina, Kimberly, Colan, Steven
• Format: Article
• Language: English
• Subjects: Biomarkers; Cardiology; Cardiomyopathy; Cardiovascular; Collagen; Heart failure; Internal Medicine; Metabolism; Pediatrics
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(16)31510-8

Cardiac Biomarker Class HCM (N=22) Mean ± SD (range) Normal Values Mean (range) 1.Collagen Metabolism (Cardiac Fibrosis)   C-Terminal Relopeptide of Type I Collagen (ng/ml) 1.2±0.5 (0.2-2.3) 0.3* (0.02-0.58) TIMP Metallopeptidase Inhibitor 1 (ng/ml) 66±13.8 (44.6-104.9) 98* (110-966) Promatrix Metalloprotease 1 (ng/ml) 2.3±2.1 (0.3-9.1) 3.45 (0.91-9.34) C-Terminal Propeptide of Type I Collagen (ng/ml) 245±146.7 (53.7-636.3) 326 (110-966) 2.Heart Failure   NT-proBNP (pg/ml) 2,152±3,909 (29-17,729) 67.8±83.7* Galectin-3 (ng/ml) 5.4±1.8 (2.3-9.9) 6.44* (2.03-15.50) ST2 (pg/ml) 11,937±6,220 (5,308-26,305) 12.2* (4.90-19.9) Growth Differentiation Factor-15 (pg/ml) 355±100 (205-499) 534 (289-1096) 3.Cardiac Myocyte Injury   Troponin-T (cTnT) (level of detection >= 0.01 ng/ml) 0.08±0.06 N=3 (0.04-0.15) [N=19 had non-detectable levels]