Adoptive therapy with CAR redirected T cells for hematological malignancies

• Published in: Science China. Life sciences 2016-04, Vol.59 (4), p.370-378
• Main Authors: Li, Shiqi, Yang, Zhi, Shen, Junjie, Shan, Juanjuan, Qian, Cheng
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Cytokines - secretion; Genetic Engineering - methods; Hematologic Neoplasms - genetics; Hematologic Neoplasms - immunology; Hematologic Neoplasms - therapy; Humans; Immunotherapy, Adoptive - methods; Life Sciences; Neurotoxicity Syndromes - etiology; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell - metabolism; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Recombinant Fusion Proteins - metabolism; Review; Syndrome; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - transplantation; T细胞; 恶性肿瘤; 汽车; 治疗药物; 细胞工程; 肿瘤患者; 血液系统; 重定向
• ISSN: 1674-7305; 1869-1889
• DOI: 10.1007/s11427-016-5036-3

The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor（CAR） were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.